{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:26:49Z","timestamp":1792787209851,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Cardiac resynchronization therapy utilizing biventricular pacing is an effective therapy for patients with left ventricular (LV) systolic dysfunction, left bundle branch block, and heart failure. Benefits of biventricular pacing may be limited in patients with right bundle branch block (RBBB). Permanent His bundle pacing (HBP) has recently been reported as an option for cardiac resynchronization therapy. The aim of the study was to assess the feasibility and outcomes of HBP in patients with RBBB and heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec sec-type=\"methods\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p>HBP was attempted as a primary or rescue (failed LV lead implant) strategy in patients with reduced LV ejection fraction, RBBB, QRS duration \u2265120 ms, and New York Heart Association class II to IV heart failure. Implant characteristics, New York Heart Association functional class, and echocardiographic data were assessed in follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec sec-type=\"results\">\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              Mean age was 72\u00b110 years, female 15%, with an average LV ejection fraction of 31\u00b110%. HBP was successful in 37 of 39 patients (95%) with narrowing of RBBB in 78% cases. His capture and bundle branch block correction thresholds were 1.1\u00b10.6 V and 1.4\u00b10.7 V at 1 ms, respectively. During a mean follow-up of 15\u00b123 months, there was a significant narrowing of QRS from 158\u00b124 to 127\u00b117 ms (\n              <jats:italic>P<\/jats:italic>\n              =0.0001), increase in LV ejection fraction from 31\u00b110% to 39\u00b113% (\n              <jats:italic>P<\/jats:italic>\n              =0.004), and improvement in New York Heart Association functional class from 2.8\u00b10.6 to 2\u00b10.7 (\n              <jats:italic>P<\/jats:italic>\n              =0.0001) with HBP. Increase in capture threshold occurred in 3 patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Permanent HBP was associated with significant narrowing of QRS duration and improvement in LV function in patients with RBBB and reduced LV ejection fraction. Permanent HBP is a promising option for cardiac resynchronization therapy in patients with RBBB and reduced LV ejection fraction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.118.006613","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:34:48Z","timestamp":1537104888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":147,"title":["Permanent His Bundle Pacing for Cardiac Resynchronization Therapy in Patients With Heart Failure and Right Bundle Branch Block"],"prefix":"10.1161","volume":"11","author":[{"given":"Parikshit S.","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center, Chicago, IL (P.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Naperkowski","sequence":"additional","affiliation":[{"name":"Geisinger Heart Institute, Wilkes-Barre, PA (A.N., T.D.B., P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry D.","family":"Bauch","sequence":"additional","affiliation":[{"name":"Geisinger Heart Institute, Wilkes-Barre, PA (A.N., T.D.B., P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Y.S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chinese University of Hong Kong, (J.Y.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahran D.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Imperial College London, United Kingdom (A.D.A., Z.I.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary I.","family":"Whinnett","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Imperial College London, United Kingdom (A.D.A., Z.I.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Virginia Commonwealth University Health System, Richmond (K.A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugazhendhi","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Geisinger Heart Institute, Wilkes-Barre, PA (A.N., T.D.B., P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2685"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441202"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01895-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.11.014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus228"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.021"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.10.014"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.048"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.10.039"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.074"},{"key":"e_1_3_2_19_2","volume-title":"Paper presented at: Heart Rhythm Society Scientific Sessions","author":"Singh JP","unstructured":"Singh, JP. 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