{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:27:46Z","timestamp":1791419266179,"version":"4.3.3"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endocardial pacemaker leads and right ventricular (RV) pacing are well-known causes of tricuspid valve, mitral valve, and cardiac dysfunction. Lead-related adverse consequences can potentially be mitigated by leadless pacemaker (LP) therapy by eliminating the presence of a transvalvular lead. This study assessed the impact of LP placement on cardiac and valvular structure and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Echocardiographic studies before and 12\u00b11 months after LP implantation were performed between January 2013 and May 2018 at our center and compared with age- and sex-matched controls of dual-chamber transvenous pacemaker recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 53 patients receiving an LP were included, of whom 28 were implanted with a Nanostim and 25 with a Micra LP device. Tricuspid valve regurgitation was graded as being more severe in 23 (43%) patients at 12\u00b11 months compared with baseline (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Compared with an apical position, an RV septal position of the LP was associated with increased tricuspid valve incompetence (odds ratio, 5.20;\n                      <jats:italic>P<\/jats:italic>\n                      =0.03). An increase in mitral valve regurgitation was observed in 38% of patients (\n                      <jats:italic>P<\/jats:italic>\n                      =0.006). LP implantation resulted in a reduction of RV function, according to a lower tricuspid annular plane systolic excursion (\n                      <jats:italic>P<\/jats:italic>\n                      =0.003) and RV tricuspid lateral annular systolic velocity (\n                      <jats:italic>P<\/jats:italic>\n                      =0.02), and a higher RV Tei index (\n                      <jats:italic>P<\/jats:italic>\n                      =0.04). LP implantation was further associated with a reduction of left ventricular ejection fraction (\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) and elevated left ventricular Tei index (\n                      <jats:italic>P<\/jats:italic>\n                      =0.003). The changes in tricuspid valve regurgitation in the LP group were similar to the changes in the dual-chamber transvenous pacemaker control group (43% versus 38%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      =0.39).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LP therapy is associated with an increase in tricuspid valve dysfunction through 12 months of follow-up; yet it was comparable to dual-chamber transvenous pacemaker systems. Furthermore, LP therapy seems to adversely impact mitral valve and biventricular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.118.007124","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T13:27:12Z","timestamp":1557235632000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":123,"title":["Impact of Leadless Pacemaker Therapy on Cardiac and Atrioventricular Valve Function Through 12 Months of Follow-Up"],"prefix":"10.1161","volume":"12","author":[{"given":"Niek E.G.","family":"Beurskens","sequence":"first","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur V.Y.","family":"Tjong","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne H.A.","family":"de Bruin-Bon","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosse J.","family":"Dasselaar","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichert J.","family":"Kuijt","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinoud E.","family":"Knops","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, the 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