{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:57:15Z","timestamp":1784329035283,"version":"3.55.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Data characterizing structural changes of arrhythmogenic right ventricular (RV) cardiomyopathy are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients presenting with left bundle branch block ventricular tachycardia in the setting of arrhythmogenic RV cardiomyopathy with procedures separated by at least 9 months were included.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Nineteen consecutive patients (84% males; mean age 39\u00b115 years [range, 20\u201376 years]) were included. All 19 patients underwent 2 detailed sinus rhythm electroanatomic endocardial voltage maps (average 385\u00b1177 points per map; range, 93\u2013847 points). Time interval between the initial and repeat ablation procedures was mean 50\u00b137 months (range, 9\u2013162). No significant progression of voltage was observed (bipolar: 38 cm\n              <jats:sup>2<\/jats:sup>\n              [interquartile range (IQR), 25\u201354] versus 53 cm\n              <jats:sup>2<\/jats:sup>\n              [IQR, 25\u201365],\n              <jats:italic>P<\/jats:italic>\n              =0.09; unipolar: 116 cm\n              <jats:sup>2<\/jats:sup>\n              [IQR, 61\u2013209] versus 159 cm\n              <jats:sup>2<\/jats:sup>\n              [IQR, 73\u2013204],\n              <jats:italic>P<\/jats:italic>\n              =0.36) for the entire study group. There was a significant increase in RV volumes (percentage increase, 28%; 206 mL [IQR, 170\u2013253] versus 263 mL [IQR, 204\u2013294],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for the entire study population. Larger scars at baseline but not changes over time were associated with a significant increase in RV volume (bipolar: Spearman \u03c1, 0.6965,\n              <jats:italic>P<\/jats:italic>\n              =0.006; unipolar: Spearman \u03c1, 0.5743,\n              <jats:italic>P<\/jats:italic>\n              =0.03). Most patients with progressive RV dilatation (8\/14, 57%) had moderate (2 patients) or severe (6 patients) tricuspid regurgitation recorded at either initial or repeat ablation procedure.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In patients with arrhythmogenic RV cardiomyopathy presenting with recurrent ventricular tachycardia, &gt;10% increase in RV endocardial surface area of bipolar voltage consistent with scar is uncommon during the intermediate term. Most recurrent ventricular tachycardias are localized to regions of prior defined scar. Voltage indexed scar area at baseline but not changes in scar over time is associated with progressive increase in RV size and is consistent with adverse remodeling but not scar progression. Marked tricuspid regurgitation is frequently present in patients with arrhythmogenic RV cardiomyopathy who have progressive RV dilation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.119.007611","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T21:16:23Z","timestamp":1578690983000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of Structural Changes in Arrhythmogenic Right Ventricular Cardiomyopathy With Recurrent Ventricular Tachycardia After Ablation"],"prefix":"10.1161","volume":"13","author":[{"given":"David F.","family":"Brice\u00f1o","sequence":"first","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Markman","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Chahal","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"Tschabrunn","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Zado","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew C.","family":"Hyman","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanan","family":"Kumareswaran","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery S.","family":"Arkles","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Supple","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Deo","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Riley","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lin","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin C.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Dixit","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1509267"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003562"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.834903"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.963066"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12858"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5034"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13853"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.919530"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.840827"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.215"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00559.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.11.1288"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959957"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13630"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021498"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.960740"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5035"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.119.007611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:12:02Z","timestamp":1715559122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.119.007611"}},"subtitle":["Insights From Repeat Electroanatomic Voltage Mapping"],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1161\/CIRCEP.119.007611"],"URL":"https:\/\/doi.org\/10.1161\/circep.119.007611","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007611"}}