{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:52Z","timestamp":1787018032555,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To facilitate ablation of ventricular tachycardia (VT), an automated localization system to identify the site of origin of left ventricular activation in real time using the 12-lead ECG was developed. The objective of this study was to prospectively assess its accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The automated site of origin localization system consists of 3 steps: (1) localization of ventricular segment based on population templates, (2) population-based localization within a segment, and (3) patient-specific site localization. Localization error was assessed by the distance between the known reference site and the estimated site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 19 patients undergoing 21 catheter ablation procedures of scar-related VT, site of origin localization accuracy was estimated using 552 left ventricular endocardial pacing sites pooled together and 25 VT-exit sites identified by contact mapping. For the 25 VT-exit sites, localization error of the population-based localization steps was within 10 mm. Patient-specific site localization achieved accuracy of within 3.5 mm after including up to 11 pacing (training) sites. Using 3 remotes (67.8\u00b117.0 mm from the reference VT-exit site), and then 5 close pacing sites, resulted in localization error of 7.2\u00b14.1 mm for the 25 identified VT-exit sites. In 2 emulated clinical procedure with 2 induced VTs, the site of origin localization system achieved accuracy within 4 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this prospective validation study, the automated localization system achieved estimated accuracy within 10 mm and could thus provide clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.119.008262","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T05:27:03Z","timestamp":1592198823000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Prospective Assessment of an Automated Intraprocedural 12-Lead ECG-Based System for Localization of Early Left Ventricular Activation"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-8921","authenticated-orcid":true,"given":"Shijie","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering (S.Z., N.A.T.), Johns Hopkins University, Baltimore, MD."},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation (S.Z., N.A.T.), Johns Hopkins University, Baltimore, MD."},{"name":"Heart Rhythm Service, Cardiology Division, Department of Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S.Z., A.A., J.S.D., I.E., D.C.L., C.J.M., R.P., C.J.G., M.J.G., C.M., R.C., J.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-6892","authenticated-orcid":true,"given":"Amir","family":"AbdelWahab","sequence":"additional","affiliation":[{"name":"Heart Rhythm Service, Cardiology Division, Department of Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S.Z., A.A., J.S.D., I.E., D.C.L., C.J.M., R.P., C.J.G., M.J.G., C.M., R.C., J.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Milan","family":"Hor\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (B.M.H.), Dalhousie University, Halifax, NS, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics (P.J.M., J.W.W., J.L.S.), Dalhousie University, Halifax, NS, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Warren","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics (P.J.M., J.W.W., J.L.S.), Dalhousie University, Halifax, NS, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Heart Rhythm Service, Cardiology Division, Department of Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S.Z., A.A., J.S.D., I.E., D.C.L., C.J.M., R.P., C.J.G., 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