{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:53:36Z","timestamp":1791726816652,"version":"4.3.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Pulsed field ablation (PFA) is a novel form of ablation using electrical fields to ablate cardiac tissue. There are only limited data assessing the feasibility and safety of this type of ablation in humans.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              PULSED AF (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF;\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; unique identifier: NCT04198701) is a nonrandomized, prospective, multicenter, global, premarket clinical study. The first-in-human pilot phase evaluated the feasibility and efficacy of pulmonary vein isolation using a novel PFA system delivering bipolar, biphasic electrical fields through a circular multielectrode array catheter (PulseSelect; Medtronic, Inc). Thirty-eight patients with paroxysmal or persistent atrial fibrillation were treated in 6 centers in Australia, Canada, the United States, and the Netherlands. The primary outcomes were ability to achieve acute pulmonary vein isolation intraprocedurally and safety at 30 days.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Acute electrical isolation was achieved in 100% of pulmonary veins (n=152) in the 38 patients. Skin-to-skin procedure time was 160\u00b191 minutes, left atrial dwell time was 82\u00b135 minutes, and fluoroscopy time was 28\u00b19 minutes. No serious adverse events related to the PFA system occurred in the 30-day follow-up including phrenic nerve injury, esophageal injury, stroke, or death.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In this first-in-human clinical study, 100% pulmonary vein isolation was achieved using only PFA with no PFA system\u2013related serious adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphic Abstract:<\/jats:title>\n            <jats:p>A graphic abstract is available for this article.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.121.010168","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T10:00:44Z","timestamp":1640772044000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":194,"title":["First-in-Human Experience and Acute Procedural Outcomes Using a Novel Pulsed Field Ablation System: The PULSED AF Pilot Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-9727","authenticated-orcid":true,"given":"Atul","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Cardiology, Southlake Regional Health Centre, Newmarket, Canada (A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-4220","authenticated-orcid":true,"given":"Lucas","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Amsterdam, the Netherlands (L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Haines","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beaumont Hospital, Royal Oak, MI (D.E.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0728","authenticated-orcid":true,"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. David\u2019s Hospital, Austin, TX (A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":true,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital of the University of Pennsylvania, Philadelphia (F.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-8429","authenticated-orcid":true,"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Adelaide Hospital, Australia (P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-9433","authenticated-orcid":true,"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins Hospital, Baltimore, MD (H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-869X","authenticated-orcid":true,"given":"Douglas L.","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Rochester, NY (D.L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-2553","authenticated-orcid":true,"given":"John","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, OSU Wexner Medical Center, Columbus, OH (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-8939","authenticated-orcid":true,"given":"Birce","family":"Onal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medtronic, Minneapolis, MN (B.O., S.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofi","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medtronic, Minneapolis, MN (B.O., S.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-3870","authenticated-orcid":true,"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center L\u00fcbeck, Germany (K.-H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Leipzig, Germany 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