{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:51:49Z","timestamp":1792803109442,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Left bundle branch pacing (LBBP) has emerged as an alternative to biventricular pacing (BVP) for delivering cardiac resynchronization therapy. We sought to compare the acute improvement of electrical and mechanical synchrony, and hemodynamics between LBBP and BVP in patients with heart failure and left bundle branch block.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      LBBP and BVP were performed and compared in a crossover fashion in patients with heart failure and left bundle branch block undergoing cardiac resynchronization therapy implantation. Electrical synchrony was assessed by QRS duration and area, mechanical synchrony by the SD of time to peak velocity of 12 left ventricular segments (Ts-SD) and interventricular mechanical delay, and hemodynamics by the maximum rate of left ventricular pressure rise (dP\/dt\n                      <jats:sub>max<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-one patient with heart failure and left bundle branch block (mean age 67\u00b110 years, 48% male, and 90% nonischemic cause) were included. Both LBBP and BVP provided significant improvements in electrical and mechanical synchrony, and hemodynamics compared to the baseline. Compared with BVP, LBBP achieved a larger reduction in QRS duration (\u221211 ms [95% CI, \u221217 to \u22124 ms];\n                      <jats:italic>P<\/jats:italic>\n                      =0.003) and QRS area (\u221285 \u00b5Vs [95% CI, \u2212113 to \u221256 \u00b5Vs];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001); LBBP achieved a greater decrease in Ts-SD (\u221214 ms [95% CI, \u221221 to \u22127 ms];\n                      <jats:italic>P<\/jats:italic>\n                      =0.001), with no significant difference in interventricular mechanical delay (\u22122 ms [95% CI, \u221213 to 8 ms];\n                      <jats:italic>P<\/jats:italic>\n                      =0.63). The increase in dP\/dt\n                      <jats:sub>max<\/jats:sub>\n                      from LBBP was significantly higher than that from BVP (6% [95% CI, 2%\u20139%];\n                      <jats:italic>P<\/jats:italic>\n                      =0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LBBP delivers greater acute electrical and mechanical resynchronization and hemodynamic improvement than BVP in predominantly nonischemic heart failure patients with left bundle branch block.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04505384.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.122.011181","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T13:40:56Z","timestamp":1666964456000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure"],"prefix":"10.1161","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct04505384","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-8958","authenticated-orcid":true,"given":"Yixiu","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Deltahealth Hospital (X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-6802","authenticated-orcid":true,"given":"Hongyang","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management, Medtronic Technology Center, Medtronic (Shanghai) Ltd (H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital of Shanghai Jiao Tong University, China (W.Z., R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruogu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital of Shanghai Jiao Tong University, China (W.Z., 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