{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:36:22Z","timestamp":1772519782655,"version":"3.50.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The implications of a drug-induced type 1 Brugada ECG pattern following sodium channel blocker provocation (SCBP) are not fully understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Baseline clinical and ECG data were obtained from consecutive unexplained cardiac arrest survivors undergoing SCBP at 3 centers. A further 15 SCBP positive (SCBP+) unexplained cardiac arrest survivors were recruited from 3 additional centers to explore ventricular fibrillation recurrence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 121 consecutive unexplained cardiac arrest survivors underwent SCBP. The yield of the drug-induced type 1 Brugada ECG pattern was 17%. A baseline type 2\/3 Brugada pattern (T2\/3BP) (adjusted odds ratio, 19.36 [2.74\u2013136.61];\n              <jats:italic>P<\/jats:italic>\n              =0.003) and PR interval (odds ratio, 1.03 [1.01\u20131.05] per ms;\n              <jats:italic>P<\/jats:italic>\n              =0.017) were independent predictors of SCBP+ response. A pathogenic\n              <jats:italic>SCN5A<\/jats:italic>\n              variant was identified in 36% of the SCBP+ group versus 0% in the SCBP\u2212 group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Amongst SCBP+ patients, a spontaneous type 1 Brugada pattern was identified in 19% during follow up and in 24% a type 1 Brugada pattern was identified in a relative. Prior syncope (adjusted hazard ratio, 3.83 [1.36\u201310.78];\n              <jats:italic>P<\/jats:italic>\n              =0.011) and the presence of global early repolarization (hazard ratio, 7.91 [3.22\u201319.44];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) were independent predictors of 5-year ventricular fibrillation recurrence. There was a nonsignificant trend toward greater 5-year ventricular fibrillation recurrence in the SCBP\u2212 group (23\/95 [24%] versus 3\/34 [9%];\n              <jats:italic>P<\/jats:italic>\n              =0.055).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              The yield of the drug-induced type 1 Brugada ECG pattern in consecutive unexplained cardiac arrest survivors undergoing SCBP is 17%. A baseline T2\/3BP and PR interval were independent predictors of the drug-induced type 1 Brugada ECG pattern. Greater heritability of BrS phenotype in this group was evidenced by a greater prevalence of pathogenic\n              <jats:italic>SCN5A<\/jats:italic>\n              variants and relatives with a type 1 Brugada pattern. A history of prior syncope and the presence of global early repolarization were independent predictors of ventricular fibrillation recurrence.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.122.011263","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T16:38:09Z","timestamp":1669653489000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["The Utility of Sodium Channel Provocation in Unexplained Cardiac Arrest Survivors and Electrocardiographic Predictors of Ventricular Fibrillation Recurrence"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9655-8708","authenticated-orcid":true,"given":"Bode","family":"Ensam","sequence":"first","affiliation":[{"name":"Cardiology Clinical Academic Group, St George\u2019s University Hospitals NHS Foundation Trust, London, United Kingdom (B.E., C.S., E.R.B.)."},{"name":"Institute of Molecular and Clinical Sciences, St George\u2019s University of London, United Kingdom (B.E., C.S., E.R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0459-3897","authenticated-orcid":true,"given":"Christopher C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver (C.C.C., A.D.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-3980","authenticated-orcid":true,"given":"Fahad","family":"Almehmadi","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (F.A., J.D.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-4712","authenticated-orcid":true,"given":"Bo","family":"Gregers 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A.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-2592","authenticated-orcid":true,"given":"Kevin","family":"Leong","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (K.L., A.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-617X","authenticated-orcid":true,"given":"Alison","family":"Muir","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital, Belfast, United Kingdom (P.B., A.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-0303","authenticated-orcid":true,"given":"Amanda","family":"Vanarva","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (K.L., 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