{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:19:11Z","timestamp":1792498751016,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The analysis of the wave-front activation patterns is crucial for the comprehension and treatment of ventricular tachycardia (VT). The ventricular electrograms duration map (VEDUM) is a potential method to identify areas (VEDUM area) with slow and inhomogeneous activation. There is no available data on the characteristics and the arrhythmogenic role of VEDUM areas identified during sinus\/paced rhythm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients referred for VT ablation were enrolled at 3 different centers. VEDUM maps during sinus\/paced rhythm as well as substrate and functional maps were created; activation mapping was performed for all hemodynamically tolerated VT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirty-two patients (mean age:70.1\u00b19.4 years; males 93.8%) were enrolled. The VEDUM approach was achieved in all patients and the mean size of the VEDUM area was 12.1\u00b16.9 cm\n                      <jats:sup>2<\/jats:sup>\n                      (interquartile range, 7.8\u201314.9 cm\n                      <jats:sup>2<\/jats:sup>\n                      ). A significative difference was observed between the electrogram duration in the VEDUM area and the normal tissue (163.7 ms [interquartile range, 142.3\u2013199.2 ms]; versus 65.5 ms [interquartile range, 59.5\u201376.2 ms];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). The VEDUM area was visualized in a dense scar (&lt;0.5 mV) in 19 (59.4%) patients. A deceleration zone and late potentials were recorded inside the VEDUM area in 56.3% and 81.3%, respectively. When a complete VT activation mapping was available, the isthmus projected in the VEDUM area in 93.5% of patients; 8 of them had multiple VTs mapped and in the 87.5% all VT isthmuses were included in the VEDUM area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>VEDUM maps allow the identification of discrete areas of inhomogeneous and slow conduction. They represent a potential target for VT ablation, including patients with multiple morphologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.122.011729","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T05:01:28Z","timestamp":1690174888000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Ventricular Electrograms Duration Map to Detect Ventricular Arrhythmia Substrate: the VEDUM Project Study"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-5609","authenticated-orcid":true,"given":"Pietro","family":"Rossi","sequence":"first","affiliation":[{"name":"Arrhythmology Unit, Ospedale Fatebenefratelli Isola Tiberina-Gemelli Isola, Rome, Italy (P.R., F.M.C., M.M., M.P., S.C., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-8070","authenticated-orcid":true,"given":"Filippo Maria","family":"Cauti","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit, Ospedale Fatebenefratelli Isola Tiberina-Gemelli Isola, Rome, Italy (P.R., F.M.C., M.M., M.P., S.C., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Niscola","sequence":"additional","affiliation":[{"name":"Abbott Medical Italy, Sesto San Giovanni, Milan, Italy (M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-0114","authenticated-orcid":true,"given":"Michele","family":"Magnocavallo","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit, Ospedale Fatebenefratelli Isola Tiberina-Gemelli Isola, Rome, Italy (P.R., F.M.C., M.M., M.P., S.C., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-8604","authenticated-orcid":true,"given":"Marco","family":"Polselli","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit, Ospedale Fatebenefratelli Isola Tiberina-Gemelli Isola, Rome, Italy (P.R., F.M.C., M.M., M.P., S.C., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-4977","authenticated-orcid":true,"given":"Silvia","family":"Capone","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit, Ospedale Fatebenefratelli Isola Tiberina-Gemelli Isola, Rome, Italy (P.R., F.M.C., M.M., M.P., S.C., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":true,"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology &amp; Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Belgium (D.G.D.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rodriguez-Garrido","sequence":"additional","affiliation":[{"name":"Hospital Universitario A Coru\u0148a, A Coru\u0148a,, Spain (J.R.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"University of Rome \u201cSapienza,\u201d Department of Science of Internal Clinics, Anestesiologists &amp; Cardiovasculars, Policlinico Umberto I, Rome, Italy (G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Anguera","sequence":"additional","affiliation":[{"name":"Arrhythmias Unit, Cardiology Department, Bellvitge University Hospital &amp; Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Unstitute (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain (I.A., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-4163","authenticated-orcid":true,"given":"Paolo","family":"Dallaglio","sequence":"additional","affiliation":[{"name":"Arrhythmias Unit, Cardiology Department, Bellvitge University Hospital &amp; 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