{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:59:03Z","timestamp":1793051943985,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Pulsed field ablation uses electrical fields to cause nonthermal cell death over several hours. Polarization-sensitive optical coherence reflectometry is an optical imaging technique that can detect changes in the tissue ultrastructure in real time, which occurs when muscular tissue is damaged. The objective of this study was to evaluate the ability of a polarization-sensitive optical coherence reflectometry system to predict the development of chronic lesions based on acute changes in tissue birefringence during pulsed field ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Superior vena cava isolation was performed in 30 swine using a biphasic, bipolar pulsed field ablation system delivered with a nonirrigated focal tip catheter. Acute changes in tissue birefringence and voltage abatement were analyzed for each individual lesion. A high-resolution electroanatomical map was performed at baseline and 4 to 12 weeks after ablation to locate electrical gaps in the ablated area.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 141 lesions were delivered and included in the analysis. Acute electrical isolation based on the electroanatomical map was achieved in 96% of the animals, but chronic isolation was only seen in 14 animals (46%). The mean voltage abatement of lesions that showed recovery was 82.8%\u00b114.6% versus 84.4%\u00b117.4% for those that showed fibrosis (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.7). The mean acute reduction in tissue birefringence in points demonstrating fibrosis was 63.8%\u00b111.3% versus 9.1%\u00b10.1% in the points that resulted in electrical gaps. A threshold of acute reduction of birefringence of \u226520% could predict chronic lesion formation with a sensitivity of 96% and a specificity of 83%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Acute tissue birefringence changes assessed with polarization-sensitive optical coherence reflectometry during pulsed field ablation can predict chronic lesion formation and guide the ablation procedure although limited by the tissue thickness.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.123.012255","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T10:00:19Z","timestamp":1707213619000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac Pulsed Field Ablation Lesion Durability Assessed by Polarization-Sensitive Optical Coherence Reflectometry"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-6723","authenticated-orcid":true,"given":"Maria","family":"Terricabras","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute, University of Toronto, ON, Canada (M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6712","authenticated-orcid":true,"given":"Raphael P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Rennes, Centres d\u2019Investigation Clinique - Innovation Technologique (CIC-IT), Laboratoire Traitement du Signal et de l\u2019Image Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (LTSI INSERM) 1099, University of Rennes, France (R.P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-0892","authenticated-orcid":true,"given":"Rafael","family":"Peinado","sequence":"additional","affiliation":[{"name":"University Hospital La Paz, Autonomous University of Madrid, Spain (R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3317-1837","authenticated-orcid":true,"given":"Pawe\u0142","family":"Derejko","sequence":"additional","affiliation":[{"name":"Medicover Hospital, Warsaw, Poland (P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-5906","authenticated-orcid":true,"given":"Llu\u00eds","family":"Mont","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic, Universitat de Barcelona, Spain (L.M.)."},{"name":"Instituto de Investigaciones Biom\u00e8dicas August Pi i Sunyer, Barcelona, Spain (L.M.)."},{"name":"Centro de Investigaci\u00f3n en Red Cardiovascular, Madrid, Spain (L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-2477","authenticated-orcid":true,"given":"Sabine","family":"Ernst","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital, Imperial College London, United Kingdom (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herranz","sequence":"additional","affiliation":[{"name":"MedLumics S.L., Tres Cantos, Spain (D.H., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-1754","authenticated-orcid":true,"given":"Christophe","family":"Bailleul","sequence":"additional","affiliation":[{"name":"MedLumics S.L., Tres Cantos, Spain (D.H., 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