{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:58:43Z","timestamp":1788566323654,"version":"build-2803163510"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>A growing number of patients with tetralogy of Fallot develop left ventricular systolic dysfunction and heart failure, in addition to right ventricular dysfunction. Although cardiac resynchronization therapy (CRT) is an established treatment option, the effect of CRT in this population is still not well defined. This study aimed to investigate the early and late efficacy, survival, and safety of CRT in patients with tetralogy of Fallot.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Data were analyzed from an observational, retrospective, multicenter cohort, initiated jointly by the Pediatric and Congenital Electrophysiology Society and the International Society of Adult Congenital Heart Disease. Twelve centers contributed baseline and longitudinal data, including vital status, left ventricular ejection fraction (LVEF), QRS duration, and NYHA functional class. Outcomes were analyzed at early (3 months), intermediate (1 year), and late follow-up (\u22652 years) after CRT implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 44 patients (40.3\u00b119.2 years) with tetralogy of Fallot and CRT were enrolled. Twenty-nine (65.9%) patients had right ventricular pacing before CRT upgrade. The left ventricular ejection fraction improved from 32% [24%\u201344%] at baseline to 42% [32%\u201350%] at early follow-up (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and remained improved from baseline thereafter (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u22640.002). The QRS duration decreased from 180 [160\u2013205] ms at baseline to 152 [133\u2013182] ms at early follow-up (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and remained decreased at intermediate and late follow-up (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u22640.001). Patients with upgraded CRT had consistent improvement in left ventricular ejection fraction and QRS duration at each time point (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u22640.004). Patients had a significantly improved New York Heart Association functional class after CRT implantation at each time point compared with baseline (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u22640.002). The transplant-free survival rates at 3, 5, and 8 years after CRT implantation were 85%, 79%, and 73%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients with tetralogy of Fallot treated with CRT consistent improvement in QRS duration, left ventricular ejection fraction, New York Heart Association functional class, and reasonable long-term survival were observed. The findings from this multicenter study support the consideration of CRT in this unique population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.123.012363","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T10:00:34Z","timestamp":1707732034000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study"],"prefix":"10.1161","volume":"17","author":[{"given":"Nawin L.","family":"Ramdat Misier","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, Rotterdam , The Netherlands (N.L.R.M., N.M.S.d.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-9005","authenticated-orcid":true,"given":"Jeremy 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(R.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-3800","authenticated-orcid":true,"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Electrophysiology Service and Adult Congenital Heart Center, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Montreal Quebec, Canada (P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-2712","authenticated-orcid":true,"given":"Philip M.","family":"Chang","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, University of Florida Health, Gainesville, FL (P.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-1653","authenticated-orcid":true,"given":"Jens C.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark (J.C.N.)."},{"name":"Department of 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