{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:13:01Z","timestamp":1793711581649,"version":"4.6.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Sacubitril\/valsartan (Sac\/Val) is superior to angiotensin-converting enzyme inhibitors in reducing the risk of heart failure hospitalization and cardiovascular death, but its mechanistic data on myocardial scar after myocardial infarction (MI) are lacking. The objective of this work was to assess the effects of Sac\/Val on inflammation, fibrosis, electrophysiological properties, and ventricular tachycardia inducibility in post-MI scar remodeling in swine.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>After MI, 22 pigs were randomized to receive \u03b2-blocker (BB; control, n=8) or BB+Sac\/Val (Sac\/Val, n=9). The systemic immune response was monitored. Cardiac magnetic resonance data were acquired at 2-day and 29-day post MI to assess ventricular remodeling. Programmed electrical stimulation and high-density mapping were performed at 30-day post MI to assess ventricular tachycardia inducibility. Myocardial samples were collected for histological analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Compared with BB, BB+Sac\/Val reduced acute circulating leukocytes (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.009) and interleukin-12 levels (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.024) at 2-day post MI, decreased C-C chemokine receptor type 2 expression in monocytes (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.047) at 15-day post MI, and reduced scar mass (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.046) and border zone mass (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.043). It also lowered the number and mass of border zone corridors (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.009 and\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.026, respectively), scar collagen I content (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.049), and collagen I\/III ratio (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.040). Sac\/Val reduced ventricular tachycardia inducibility (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.034) and the number of deceleration zones (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.016).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>After MI, compared with BB, BB+Sac\/Val was associated with reduced acute systemic inflammatory markers, reduced total scar and border zone mass on late gadolinium-enhanced magnetic resonance imaging, and lower ventricular tachycardia inducibility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.123.012517","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T09:00:34Z","timestamp":1714122034000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Antiarrhythmic and Anti-Inflammatory Effects of Sacubitril\/Valsartan on Post-Myocardial Infarction Scar"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-0542","authenticated-orcid":true,"given":"Daina","family":"Mart\u00ednez-Falguera","sequence":"first","affiliation":[{"name":"ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.)."},{"name":"Faculty of Medicine, University of Barcelona, Spain (D.M.-F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-6297","authenticated-orcid":true,"given":"J\u00falia","family":"Arany\u00f3","sequence":"additional","affiliation":[{"name":"Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.)."},{"name":"Department of Medicine, Autonomous University of Barcelona, Spain (J.A., A.B.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-0736","authenticated-orcid":true,"given":"Albert","family":"Teis","sequence":"additional","affiliation":[{"name":"Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Ferrer-Curriu","sequence":"additional","affiliation":[{"name":"ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-0810","authenticated-orcid":true,"given":"Marta","family":"Mongui\u00f3-Tortajada","sequence":"additional","affiliation":[{"name":"ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.)."},{"name":"Department of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland (M.M.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-224X","authenticated-orcid":true,"given":"Edgar","family":"Fadeuilhe","sequence":"additional","affiliation":[{"name":"Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-5657","authenticated-orcid":true,"given":"Oriol","family":"Rodr\u00edguez-Leor","sequence":"additional","affiliation":[{"name":"Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.)."},{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (O.R.-L., S.R., R.V., A.B-G., F.B., C.G.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"D\u00edaz-G\u00fcemes","sequence":"additional","affiliation":[{"name":"ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Roura","sequence":"additional","affiliation":[{"name":"ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.)."},{"name":"Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.)."},{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (O.R.-L., S.R., R.V., A.B-G., F.B., C.G.-M.)."},{"name":"Faculty of Medicine, University 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