{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:19:10Z","timestamp":1793881150592,"version":"4.7.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Cardiac magnetic resonance imaging (CMR)\u2013defined ventricular scar and anatomic conduction channels (CMR-CCs) offer promise in delineating ventricular tachycardia substrate. No studies have validated channels with coregistered histology, nor have they ascertained the histological characteristics of deceleration zones (DZs) within these channels. We aimed to validate CMR scar and CMR-CCs with whole-heart histology and electroanatomic mapping in a postinfarction model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Five sheep underwent anteroseptal infarction. CMR (116\u00b120 days post infarct) was postprocessed using ADAS-3D, varying pixel intensity thresholds (5545, 6040, 6535, and 7030). DZs were identified by electroanatomic mapping (129\u00b112 days post infarct). Explanted hearts were sectioned and stained with Picrosirius red, and whole-heart histopathologic shells were generated. Scar topography as well as percentage fibrosis, adiposity, and remaining viable myocardium within 3 mm histological biopsies and within CMR-CCs were determined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Using the standard 6040 thresholding, CMR had 83.8% accuracy for identifying histological scar in the endocardium (\u03ba, 0.666) and 61.4% in the epicardium (\u03ba, 0.276). Thirty-seven CMR-CCs were identified by varying thresholding; 23 (62%) were unique. DZs colocalized to 19 of 23 (83%) CMR-CCs. Twenty (87%) CMR-CCs were histologically confirmed. Within-channel histological fibrosis did not differ by the presence of DZs (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.242). Within-channel histological adiposity was significantly higher at sites with versus without DZs (24.1% versus 8.3%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Postprocessed CMR-derived scars and channels were validated by histology and electroanatomic mapping. Regions of CMR-CCs at sites of DZs had higher adiposity but similar fibrosis than regions without DZs, suggesting that lipomatous metaplasia may contribute to arrhythmogenicity of postinfarction scar.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.124.012922","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T09:18:07Z","timestamp":1724836687000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Whole-Heart Histological and Electroanatomic Assessment of Postinfarction Cardiac Magnetic Resonance Imaging Scar and Conducting Channels"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-9289","authenticated-orcid":true,"given":"Kasun","family":"De Silva","sequence":"first","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, New South Wales, Australia (K.D.S., T.C., R.G.B., S.T., D.S., A.B., Y.K., C.-j.H., J.J.H.C., E.K., S.K.)."},{"name":"Westmead Applied Research Centre, The University of Sydney, New South Wales, Australia (K.D.S., T.C., R.G.B., C.D., S.T., A.B., Y.K., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-7741","authenticated-orcid":true,"given":"Timothy","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, New South Wales, Australia (K.D.S., T.C., R.G.B., S.T., D.S., A.B., Y.K., C.-j.H., J.J.H.C., E.K., S.K.)."},{"name":"Westmead Applied Research Centre, The University of Sydney, New South Wales, Australia (K.D.S., T.C., R.G.B., C.D., S.T., A.B., Y.K., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-3993","authenticated-orcid":true,"given":"Richard G.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, New South Wales, Australia (K.D.S., T.C., R.G.B., S.T., D.S., A.B., Y.K., C.-j.H., J.J.H.C., E.K., S.K.)."},{"name":"Westmead Applied Research Centre, The University of Sydney, New South Wales, Australia (K.D.S., T.C., R.G.B., C.D., S.T., A.B., Y.K., S.K.)."},{"name":"Division of Cardiology, University of British Columbia, Vancouver, Canada (R.G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-7507","authenticated-orcid":true,"given":"Robert D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital, and Faculty of Medicine, Dentistry, and Health Science, University of Melbourne, Victoria, Australia (R.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Davey","sequence":"additional","affiliation":[{"name":"Westmead Applied Research Centre, The University of Sydney, New South Wales, Australia (K.D.S., T.C., R.G.B., C.D., S.T., A.B., Y.K., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra K.","family":"O\u2019Donohue","sequence":"additional","affiliation":[{"name":"Bioengineering and Molecular Medicine Laboratory, The Children\u2019s Hospital at Westmead and The Westmead Institute for Medical Research, New South Wales, Australia (A.K.O., A.S.)."},{"name":"School of Chemical and Biomolecular Engineering, Faculty of Engineering, University of Sydney, New South Wales, Australia (A.K.O., A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-6281","authenticated-orcid":true,"given":"Aaron","family":"Schindeler","sequence":"additional","affiliation":[{"name":"Bioengineering and Molecular Medicine Laboratory, The Children\u2019s Hospital at Westmead and The Westmead Institute for Medical Research, New South Wales, Australia (A.K.O., A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-6689","authenticated-orcid":true,"given":"Samual","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, New South Wales, Australia (K.D.S., T.C., R.G.B., S.T., D.S., A.B., Y.K., C.-j.H., J.J.H.C., E.K., S.K.)."},{"name":"Westmead Applied Research Centre, The University of Sydney, New South Wales, Australia (K.D.S., T.C., R.G.B., C.D., S.T., A.B., Y.K., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Selvakumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, New South Wales, Australia (K.D.S., T.C., R.G.B., S.T., D.S., A.B., Y.K., C.-j.H., J.J.H.C., E.K., S.K.)."},{"name":"Centre for Heart Research, The Westmead Institute for Medical Research, New South Wales, Australia (D.S., J.J.H.C., 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