{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:42:43Z","timestamp":1792885363806,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Patients with arrhythmogenic mitral valve prolapse syndrome are at increased risk for life-threatening ventricular arrhythmias, but studies have been limited by small sample sizes. We sought to assemble an international arrhythmogenic mitral valve prolapse syndrome registry to delineate the clinical, imaging, and treatment characteristics of patients with arrhythmogenic mitral valve prolapse syndrome who survived sudden cardiac arrest (SCA) or had sustained ventricular tachycardia (VT) or ventricular fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In this descriptive registry, we characterized patients with arrhythmogenic mitral valve prolapse syndrome who survived SCA, sustained VT, or ventricular fibrillation. Deidentified data were abstracted locally and combined centrally.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>We included 148 patients who had SCA or VT\/ventricular fibrillation. Patients had a mean age of 43.7\u00b115.4 years; 68% were women, 73% had bileaflet prolapse, 65% had mitral annular disjunction, 67% had nonsustained VT, and 59% had inferolateral T-wave inversions. Syncope (n=54, 48%) and anterolateral T-wave inversion (n=26, 22%) were relatively common. Catheter ablation was performed in 50 (35%) patients for premature ventricular complexes and in 18 (17.7%) patients for VT. Sites of origin for arrhythmias were commonly in the papillary muscles, fascicles, mitral annulus, and inferior\/inferolateral left ventricle.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this international descriptive registry of patients with arrhythmogenic mitral valve prolapse syndrome and SCA, patients were young, women, and had bileaflet mitral valve prolapse, mitral annular disjunction, inferolateral T-wave inversions, and nonsustained VT. A history of syncope and anterolateral T-wave inversions was relatively common in patients who survived SCA or sustained VT\/ventricular fibrillation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.124.013099","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:00:25Z","timestamp":1740045625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-4666","authenticated-orcid":true,"given":"Apurba","family":"Chakrabarti","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Michigan, Ann Arbor (A.C., A.D., M.G., F.B., J.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-0265","authenticated-orcid":true,"given":"John R.","family":"Giudicessi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (J.R.G., F.M.E., M.J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-4557","authenticated-orcid":true,"given":"Fatima M.","family":"Ezzeddine","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (J.R.G., F.M.E., M.J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-4096","authenticated-orcid":true,"given":"Francesca N.","family":"Delling","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco (F.N.D., S.D., Y.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Dixit","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco (F.N.D., S.D., Y.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2348-2520","authenticated-orcid":true,"given":"Yoo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco (F.N.D., S.D., Y.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4323-5988","authenticated-orcid":true,"given":"Daniele","family":"Muser","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, University of Udine, Italy (D. Muser)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-5564","authenticated-orcid":true,"given":"Silvia","family":"Magnani","sequence":"additional","affiliation":[{"name":"Cardiology Department and Intensive Care Unit, San Paolo Hospital, Universit\u00e0 degli Studi di Milano, Italy (S. Magnani)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8945","authenticated-orcid":true,"given":"Aniek","family":"Van Wijngaarden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (A.V.W., N.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5769","authenticated-orcid":true,"given":"Nina","family":"Ajmone Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (A.V.W., N.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Centre, Mount Sinai School of Medicine, New York, NY (M.A.M., J.G., M.G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Centre, Mount Sinai School of Medicine, New York, NY (M.A.M., J.G., M.G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-3267","authenticated-orcid":true,"given":"Maria G.","family":"Trivieri","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Centre, Mount Sinai School of Medicine, New York, NY (M.A.M., J.G., M.G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-9739","authenticated-orcid":true,"given":"Jonaz","family":"Font","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Caen, France (J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6712","authenticated-orcid":true,"given":"Raphael","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier Universitaire de Rennes, France (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-8721","authenticated-orcid":true,"given":"James A.","family":"McCaffrey","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (J.A.M.C., F.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":true,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH (P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":true,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (J.A.M.C., F.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9284-5205","authenticated-orcid":true,"given":"Himal","family":"Chapagain","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University of Pittsburgh, PA (H.C., D. 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