{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:24:24Z","timestamp":1784013864855,"version":"3.55.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent programmed electrical stimulation, LGE-cardiac magnetic resonance, and 123-iodine meta-iodobenzylguanidine imaging between 2011 and 2019 were included. The presence of LGE and global and regional sympathetic denervation on 123-iodine meta-iodobenzylguanidine were evaluated, and patients were followed for the occurrence of VA. Global denervation was assessed using the heart-to-mediastinum ratio. Regional denervation was evaluated by calculating the number of denervated segments (DS), the ratio of DS, the summed defect score, and the weighted denervation size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of 75 included patients (median age 63 years [25th\u201375th interquartile range (IQR) 54\u201368], 79% male, left ventricular ejection fraction 36% [IQR, 27\u201344], 37% inducible for VA), 35 had no LGE. During 4.5\u00b11.6 years of mean follow-up, VA occurred in 8 of 35 (23%) patients without LGE and in 18 of 40 (45%) patients with LGE. Among patients without LGE, those with VA had greater regional sympathetic denervation (median number of DS 8 [IQR, 7\u201310] versus 2 [IQR, 1\u20135],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004; median ratio of DS 0.5 [IQR, 0.5\u20130.7] versus 0.2 [IQR, 0.1\u20130.4],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007; median defect score 36 [IQR, 30\u201341] versus 18 [IQR, 14\u201324],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01; median weighted denervation size 47 [IQR, 38\u201354] versus 22 [IQR, 14\u201330];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01). In bivariate analysis, the number of DS (hazard ratio, 1.25 [95% CI, 1.06\u20131.46];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006) was associated with the occurrence of VA in patients without LGE. Denervation of \u22657 segments identified patients without LGE at risk for VA (area under the curve, 0.83; sensitivity, 88%; specificity, 89%). Among patients with LGE, the innervation state was not associated with VA during follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with nonischemic cardiomyopathy without LGE the extent of regional denervation may contribute to risk stratification for VA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.124.013150","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:00:11Z","timestamp":1753434011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-3299","authenticated-orcid":true,"given":"Christiane","family":"Jungen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"West German Heart and Vascular Center, Department of Cardiology and Vascular Medicine, University Hospital Essen, Germany (C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Sophia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Department of Anatomy &amp; Embryology, Leiden University Medical Centre, the Netherlands (H.S.C., M.R.M.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-0136","authenticated-orcid":true,"given":"Adrianus P.","family":"Wijnmaalen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-8270","authenticated-orcid":true,"given":"Petra","family":"Dibbets-Schneider","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, the Netherlands (P.D.S., R.J.v.d.G., L.F.d.G.O., H.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-2732","authenticated-orcid":true,"given":"Augusto","family":"Meretta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-6384","authenticated-orcid":true,"given":"Sebastiaan R.","family":"Piers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-2607","authenticated-orcid":true,"given":"Alexander F.A.","family":"Androulakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."},{"name":"Willem Einthoven Center of Arrhythmia Research and Management (WECAM), Leiden, the Netherlands (C.J., H.S.C., A.P.W., A.M., S.R.P., Y.K., A.F.A.A., A.J.H.A.S., M.R.M.J., K.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-5597","authenticated-orcid":true,"given":"Rob J.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, the Netherlands (P.D.S., R.J.v.d.G., 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