{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:02:02Z","timestamp":1789574522284,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The safety of subcutaneous implantable cardioverter defibrillator (S-ICD) recipients who lead active lifestyles and engage in recreational sports is unknown. We aimed to evaluate the association between lifestyle and recreational sports and the occurrence of arrhythmia- and device-related complications, appropriate and inappropriate shocks in S-ICD recipients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We assessed a cohort of young-adult (15\u201365 years) S-ICD patients, evaluated their physical activity with IPAQ (International Physical Activity Questionnaire), and assessed the association between lifestyle and recreational sports on S-ICD safety and shocks.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              We enrolled 602 S-ICD recipients (77% men; age, 46\u00b114 years). According to the IPAQ, patients were categorized as inactive subjects (26.4%), moderately active subjects (45.2%), or highly active subjects (28.4%). Among moderately\/highly active subjects, 163 (27.1%) were recreational athletes. During follow-up (47.3 [interquartile range, 27.0\u201367.6] months), 23 patients (3.8%) reached the safety end point of arrhythmia- or device-related complications, with moderately and highly active subjects showing in multivariate analysis similar incidence compared with inactive subjects (\n              <jats:italic>P<\/jats:italic>\n              =0.59 and\n              <jats:italic>P<\/jats:italic>\n              =0.83, respectively). Forty-four patients had 87 appropriate shocks. In multivariate analysis, moderately and highly active subjects showed a nonsignificantly lower incidence of appropriate shocks compared with inactive subjects (\n              <jats:italic>P<\/jats:italic>\n              =0.12 and\n              <jats:italic>P<\/jats:italic>\n              =0.11, respectively). Consistently, there was a nonsignificant lower incidence of appropriate shocks in athletes versus nonathletes (\n              <jats:italic>P<\/jats:italic>\n              =0.06). Thirty-nine patients had 46 inappropriate shocks. Moderately and highly active subjects had similar incidence of inappropriate shocks compared with inactive subjects (\n              <jats:italic>P<\/jats:italic>\n              =0.92 and\n              <jats:italic>P<\/jats:italic>\n              =0.88, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Young S-ICD patients often lead active lifestyles and participate in sports. Higher activity levels were not associated with increased implantable cardioverter defibrillator\u2013related complications or increased risk of implantable cardioverter defibrillator shocks.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.124.013365","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:01:12Z","timestamp":1740391272000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Subcutaneous Implantable Defibrillators in Young Patients: Arrhythmias, Complications, and Physical Activity"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-7764","authenticated-orcid":true,"given":"Pietro","family":"Francia","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Molecular Medicine, Sant\u2019Andrea University Hospital (P.F., C.A.), Sapienza University of Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-2739","authenticated-orcid":true,"given":"Matteo","family":"Ziacchi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, Policlinico Sant\u2019Orsola-Malpighi, University of Bologna, Italy (M.Z., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-9421","authenticated-orcid":true,"given":"Federico","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, Italy (F.M., R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-5000","authenticated-orcid":true,"given":"Paolo","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital, Bergamo, Italy (P.D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Dello Russo","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.D.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-9181","authenticated-orcid":true,"given":"Stefano","family":"Viani","sequence":"additional","affiliation":[{"name":"Second Cardiology Division, Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (S. 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