{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:16:54Z","timestamp":1792268214617,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>To address the unmet need for a smaller pacemaker for babies, a specially modified implantable pulse generator was developed containing a Medtronic Micra subassembly in a polymer header connecting to a bipolar epicardial lead. The aim of this study was to report midterm follow-up data and outcomes of patients who underwent implantation of this device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Deidentified data were collected from 12 of 15 sites in the United States implanting the pediatric implantable pulse generator between March 2022 and February 2024. All 29 patients at these 12 sites within this timeframe were included in the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The median age at implant was 15 days (range, 0 days to 3 years, including 1 outlier). The median weight was 2.3 kg (range, 1.3\u201311.4 kg). Gestational age was 28.5 weeks to term, with 23 (79%) patients born prematurely. Of those with anatomic information, 25% had congenital heart disease. The average duration of implant was 325 days (73\u2013808 days). The most recent lead impedance mean was 612 ohms (450\u2013840 ohms), ventricular capture threshold mean was 1 V @ 0.4 ms (range, 0.38\u20132.75 V), and R-wave sensing mean was 12.5 mV (3.6\u201320 mV). There were 7 generator explants (24%), removed at 6.5 to 31 months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The pediatric implantable pulse generator can be safely implanted in neonates and infants. This multicenter report demonstrates that the devices remain stable, with effective pacing, normal electrical parameters, and battery longevity aligned with projections. This novel pediatric pacemaker provides a viable alternative to standard-size generators and addresses a vital unmet need for these small patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.124.013436","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:00:42Z","timestamp":1740459642000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Multicenter Results of a Novel Pediatric Pacemaker in Neonates and Infants"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-7369","authenticated-orcid":true,"given":"Charles I.","family":"Berul","sequence":"first","affiliation":[{"name":"Children\u2019s National Hospital, Washington, DC (C.I.B., L.H., E.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-5109","authenticated-orcid":true,"given":"Lindsey","family":"Haack","sequence":"additional","affiliation":[{"name":"Children\u2019s National Hospital, Washington, DC (C.I.B., L.H., E.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1732-9780","authenticated-orcid":true,"given":"Elizabeth D.","family":"Sherwin","sequence":"additional","affiliation":[{"name":"Children\u2019s National Hospital, Washington, DC (C.I.B., L.H., E.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-7132","authenticated-orcid":true,"given":"Robert D.","family":"Whitehill","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, GA (R.D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Nash","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Colorado, Denver (D.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Norton Children\u2019s Hospital, Louisville, KY (S.D., C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-4342","authenticated-orcid":true,"given":"Christopher","family":"Johnsrude","sequence":"additional","affiliation":[{"name":"Norton Children\u2019s Hospital, Louisville, KY (S.D., C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-6241","authenticated-orcid":true,"given":"Stephanie F.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Lurie Children\u2019s Hospital of Chicago, IL (S.F.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7481-0654","authenticated-orcid":true,"given":"Marc D.","family":"LeGras","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center of Oregon, Portland (M.D.L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-8471","authenticated-orcid":true,"given":"Bradley C.","family":"Clark","sequence":"additional","affiliation":[{"name":"Masonic Children\u2019s Hospital, University of Minnesota, Minneapolis (B.C.C., E.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-7007","authenticated-orcid":true,"given":"Erick","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Masonic Children\u2019s Hospital, University of Minnesota, Minneapolis (B.C.C., E.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-8543","authenticated-orcid":true,"given":"Heather M.","family":"Giacone","sequence":"additional","affiliation":[{"name":"Lucille Packard Children\u2019s Hospital, Stanford Children\u2019s Health, Palo Alto, CA (H.M.G., S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-0105","authenticated-orcid":true,"given":"Scott","family":"Ceresnak","sequence":"additional","affiliation":[{"name":"Lucille Packard Children\u2019s Hospital, Stanford Children\u2019s Health, Palo Alto, CA (H.M.G., S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garbi\u00f1e","family":"Goya","sequence":"additional","affiliation":[{"name":"Driscoll Children\u2019s Hospital, Corpus Christi, TX (G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanier B.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina, Charleston (L.B.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam Dan","family":"Pham","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Houston (T.D.P., S.O.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9430-4147","authenticated-orcid":true,"given":"Santiago O.","family":"Valdes","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Houston (T.D.P., S.O.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-6606","authenticated-orcid":true,"given":"Edward","family":"Rhee","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital, AZ 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