{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:11:17Z","timestamp":1792537877296,"version":"4.5.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study was to assess the prevalence and clinical impact of POTS in a series of well-characterized patients with long COVID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We prospectively analyzed 467 nonhospitalized, highly symptomatic (sick leave \u226550%) patients with long COVID, and studied differences in demographics and clinical assessment outcomes between those diagnosed with POTS and the remaining long COVID patients. Examinations were performed at a median of 12 months after acute COVID-19, followed by a cardiologist evaluation with 48-hour ECG, head-up tilt test, and Active Stand Test for those with clinically suspected POTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of all long COVID patients, 143 (31%) were diagnosed with POTS, 128 (27%) did not fulfill POTS criteria, while 196 (42%) had no clinical signs of POTS. Patients with POTS were younger (mean age, 40.0 versus 44.0 versus 47.0 years, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u22640.001) and predominantly female (91%). They had significantly lower physical activity compared with the other 2 groups, as measured with the Fr\u00e4ndin-Grimby scale (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001). Heart rates during the 6-minute walk test were significantly higher in the POTS group, both during walking and at rest afterward, with a significantly shorter walking distance (448 m versus 472 m versus 509 m, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u22640.001). However, the distribution of symptoms showed no significant differences between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In this cohort of predominantly younger women with highly symptomatic long COVID, POTS is common and presents with overlapping symptoms between POTS and non-POTS patients. Long COVID POTS confers lower physical activity and capacity compared with non-POTS long COVID and should be systematically assessed in this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.124.013629","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:00:12Z","timestamp":1759222812000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and Clinical Impact of Postural Orthostatic Tachycardia Syndrome in Highly Symptomatic Long COVID"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2372-1011","authenticated-orcid":true,"given":"Mikael","family":"Bj\u00f6rnson","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine (M.B., K.W., J.B.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Wijnbladh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine (M.B., K.W., J.B.), Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8320-9948","authenticated-orcid":true,"given":"Anna","family":"T\u00f6rnberg","sequence":"additional","affiliation":[{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society (A.T., A.S.-R., A.S., M.N.B.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Women\u2019s Health and Allied Health Professionals Theme, Medical Unit Allied Health Professionals (A.T., A.S.-R., A.S., M.N.B.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Svensson-Raskh","sequence":"additional","affiliation":[{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society (A.T., A.S.-R., A.S., M.N.B.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Women\u2019s Health and Allied Health Professionals Theme, Medical Unit Allied Health Professionals (A.T., A.S.-R., A.S., M.N.B.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7642-6157","authenticated-orcid":true,"given":"Annie","family":"Svensson","sequence":"additional","affiliation":[{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society (A.T., A.S.-R., A.S., M.N.B.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Women\u2019s Health and Allied Health Professionals Theme, Medical Unit Allied Health Professionals (A.T., A.S.-R., A.S., M.N.B.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-6240","authenticated-orcid":true,"given":"Marcus","family":"St\u00e5hlberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (M.S., A.F.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Cardiology (M.S., A.F.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-2278","authenticated-orcid":true,"given":"Michael","family":"Runold","sequence":"additional","affiliation":[{"name":"Division of Immunology and Respiratory Medicine, Department of Medicine (M.R.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Respiratory Medicine and Allergy (M.R.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":true,"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (M.S., A.F.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Cardiology (M.S., A.F.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-8468","authenticated-orcid":true,"given":"Malin","family":"Nygren- Bonnier","sequence":"additional","affiliation":[{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society (A.T., A.S.-R., A.S., M.N.B.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Women\u2019s Health and Allied Health Professionals Theme, Medical Unit Allied Health Professionals (A.T., A.S.-R., A.S., M.N.B.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-0982","authenticated-orcid":true,"given":"Judith","family":"Bruchfeld","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine (M.B., K.W., J.B.), Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Infectious Diseases (J.B.), Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"WHO COVID-19 dashboard. Available from: https:\/\/covid19.who.int\/?mapFilter=cases. Accessed May 21 2025"},{"key":"e_1_3_3_3_2","unstructured":"World Health Organization. A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus 6 October 2021. World Health Organization; 2021. WHO\/2019-nCoV\/Post_COVID-19_condition\/Clinical_case_definition\/2021.1. Accessed May 21 2025"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb2408466"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01214-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02521-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13071908"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03173-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.01.009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100004108"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-37"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.06.022"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-021-09185-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01320-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.07.014"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12852"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.56098"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2024.2314874"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00703-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-021-00299-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000336"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12991"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113792"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13566"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.07.004"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00962-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-021-00798-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9710086"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.12.002"},{"key":"e_1_3_3_34_2","volume-title":"Postural Orthostatic Tachycardia Syndrome","author":"Tran SZVH","year":"2023","unstructured":"Tran SZVH. Postural Orthostatic Tachycardia Syndrome. StatPearls Publishing; 2023."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004127"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-072726"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100724"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33415-5"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03831-6"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103071"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2023.100429"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1012668"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13111606"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00917-9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology31010001"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010100"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2018.04.005"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.013"},{"key":"e_1_3_3_49_2","first-page":"5","article-title":"Vanliga folksjukdomar som debuterar tidigt i lilvet.","volume":"14","author":"Von Knorring L","year":"2011","unstructured":"Von Knorring L, Gerhard A, Paul L, Christian R, Nils L. Vanliga folksjukdomar som debuterar tidigt i lilvet. L\u00e4kartidningen. 2011;14:5.","journal-title":"L\u00e4kartidningen"},{"key":"e_1_3_3_50_2","unstructured":"Cognitive behavioral therapy in primary care 2024. Available from: https:\/\/kbtiprimarvarden.se\/teori-och-vetenskap\/statistik-for-psykisk-ohalsa\/. Accessed May 21 2025"},{"key":"e_1_3_3_51_2","unstructured":"Public health authority of sweden: swedish health authority; updated Oct 10th 2023. Available from: https:\/\/www.folkhalsomyndigheten.se\/livsvillkor-levnadsvanor\/psykisk-halsa-och-suicidprevention\/statistik-psykisk-halsa\/. Accessed May 21 2025"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02982-3"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.12.007"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71055-5"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1515486"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.670"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases11040163"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2024.03.003"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01747-y"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296707"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.124.013629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:00:28Z","timestamp":1761069628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.124.013629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1161\/CIRCEP.124.013629"],"URL":"https:\/\/doi.org\/10.1161\/circep.124.013629","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}