{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:04:13Z","timestamp":1791475453723,"version":"4.3.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Reentry (macro or localized) is historically described as multiple pathways that are separated by barriers (either anatomic or functional) and involve active and passive loops (identified by electro-anatomic and entrainment mapping, EAM\/ETM). Some reentrant atrial tachycardia (AT) cases are characterized by challenging activation patterns and unexpected ablation responses. A recent translational study, focusing on topology (TOP) and the role of boundaries, suggests that thinking topology within EAM\/ETM might offer extra control during mapping and ablation of reentrant AT. We aimed to propose and prospectively validate a workflow (EAM\/ETM+TOP) in which we integrate topological thinking within an EAM\/ETM workflow for mapping and ablation of left-sided (left atrium) AT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>The integrated workflow was performed in 88 left atrium reentrant AT cases. After EAM\/ETM, the number of loops and potential ablation strategy were verified against the number of critical and noncritical boundaries (critical boundary [CB], non-CB). Linear radiofrequency lesions were deployed to connect both CBs, preferably by one direct CB-CB line.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>EAM\/ETM+TOP-based mapping was feasible in all cases and led to a diagnosis of a 2B topology with single-loop activation in 33 cases and a\u22653B topology with dual-loop activation in 55 cases. In 87 out of 88 cases, subsequent ablation via a direct CB-CB approach (n=75), an indirect CB-non-CB-CB (n=9), or an indirect CB-non-CB-non-CB-CB approach (n=3) led to successful termination of AT. No unexpected changes in tachycardia cycle length occurred. After a median follow-up of 356 (inter-quartile range, 228\u2013537) days, 16 patients experienced recurrence of AT (18%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Thinking topology within an EAM\/ETM workflow may offer extra control during mapping and ablation of left-sided reentrant AT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.125.013780","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:00:20Z","timestamp":1749790820000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["How a Topological Mindset May Offer Extra Control During Mapping and Ablation of Left-Sided Reentrant Atrial Tachycardia"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-0013","authenticated-orcid":true,"given":"Mattias","family":"Duytschaever","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-7606","authenticated-orcid":true,"given":"Maarten","family":"De Smet","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-7820","authenticated-orcid":true,"given":"Milad","family":"El Haddad","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"De Becker","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Francois","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5231","authenticated-orcid":true,"given":"Rene","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, AZ Sint-Jan Hospital, Bruges, Belgium (M.D., M.D.S., J.M., M.E.H., B.D.B., C.F., R.T., J.-B.L.P.d.W., S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Van den Abeele","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Ghent University, Belgium (R.V.d.A., S.H., N.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8445-7070","authenticated-orcid":true,"given":"Sander","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Ghent University, Belgium (R.V.d.A., S.H., 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