{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:08:34Z","timestamp":1792210114529,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Identification of fast ventricular tachycardia (FVT; cycle length &lt;320 ms) isthmuses is often hindered by hemodynamic instability during sustained FVT and by rate-dependent (functional) scar properties. Comparing ultra-high-density voltage heterogeneity maps (0.1\u20131.5 mV) of the scar area during sinus rhythm (SR) and FVT may delineate the rate-dependent components of the FVT isthmus (FVTI) and improve substrate identification during SR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Thirty Large White swine with anterior myocardial infarction underwent cardiac magnetic resonance imaging for signal intensity mapping, followed by electrophysiological studies at 4 and 16 weeks post-infarction. FVTIs were defined as corridors of high-frequency electrograms spanning electric diastole and completing reentrant circuits in activation maps. Voltage heterogeneity mapping during FVT and SR was performed to identify voltage channels and delineate functional substrate. Statistical comparisons were performed using the Student\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test, with data presented as mean\u00b1SD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Sixty ventricular tachycardias were induced, including 27 monomorphic episodes with a cycle length &lt; 320 ms. Of these, 25 exhibited reentrant activation with identifiable FVTI. All FVTIs were housed within channels identified in voltage heterogeneity maps during FVT and signal intensity maps; 22 of 25 (88%) colocalized with a channel visible in SR voltage maps. Comparing FVT and SR voltage maps revealed that (1) dense scar area (&lt;0.1 mV) was larger in FVT than in SR maps (1.5\u00b10.3 versus 0.1\u00b10.2 cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), (2) voltage channels sustaining FVTI in FVT were longer than in SR (18.7\u00b17.1 versus 14.6\u00b16.1 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.047), and (3) while all channels in FVT maps were bordered by dense scar (&lt;0.1 mV), only 4 in SR exhibited this feature, indicating a functional substrate in 84% of FVTIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>FVTIs are located within channels identified in voltage heterogeneity maps during SR and FVT. These channels colocalize with heterogeneous tissue channels in signal intensity maps. Comparative analysis of SR and FVT voltage maps enables delineation of functional borders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.013793","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:00:47Z","timestamp":1756371647000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Scar Voltage Mapping in Fast Ventricular Tachycardia for Identifying Functional Substrates of Tachycardia Isthmuses: A Proof-of-Concept Study"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-8230","authenticated-orcid":true,"given":"Alejandro","family":"Carta-Bergaz","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Servicio de Cardiolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain (A.C.-B., J.B., A.A.-M.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (A.C.-B., J.B., A.A.-M.)."},{"name":"Facultad de Medicina, Universidad Complutense de Madrid, Spain (A.C.-B., J.B., A.A.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-3045","authenticated-orcid":true,"given":"Gonzalo R.","family":"R\u00edos-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda, Universidad Carlos III de Madrid, Spain (G.R.R.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-7029","authenticated-orcid":true,"given":"Ver\u00f3nica","family":"Cris\u00f3stomo","sequence":"additional","affiliation":[{"name":"Centro de Cirug\u00eda M\u00ednimamente Invasiva Jes\u00fas Us\u00f3n, C\u00e1ceres, Spain (V.C., C.B., V.B., F.M.S.-M.)."},{"name":"Red Espa\u00f1ola de Terapias Avanzadas RICORS-TERAV, Instituto de Salud Carlos III, Spain (V.C., C.B., V.B., F.M.S.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-2929","authenticated-orcid":true,"given":"Claudia","family":"B\u00e1ez","sequence":"additional","affiliation":[{"name":"Centro de Cirug\u00eda M\u00ednimamente Invasiva Jes\u00fas Us\u00f3n, C\u00e1ceres, Spain (V.C., C.B., V.B., F.M.S.-M.)."},{"name":"Red Espa\u00f1ola de Terapias Avanzadas RICORS-TERAV, Instituto de Salud Carlos III, Spain (V.C., C.B., V.B., F.M.S.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-919X","authenticated-orcid":true,"given":"Virginia","family":"Blanco","sequence":"additional","affiliation":[{"name":"Centro de Cirug\u00eda M\u00ednimamente Invasiva Jes\u00fas Us\u00f3n, C\u00e1ceres, Spain (V.C., C.B., V.B., F.M.S.-M.)."},{"name":"Red Espa\u00f1ola de Terapias Avanzadas RICORS-TERAV, Instituto de Salud Carlos III, Spain (V.C., C.B., V.B., 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