{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:33:39Z","timestamp":1792672419708,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Frequent nonphysiological ventricular pacing and resultant pacing-induced cardiomyopathy are well characterized in transvenous pacemakers (TVP). The incidence of pacing-induced cardiomyopathy in leadless pacemakers (LP) is less understood, particularly compared with TVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We utilized the TriNetX Analytics Network database to identify 2594 propensity score-matched patients who underwent implantation of LP and TVP between January 1, 2016, and January 1, 2023. The primary outcome was the incidence of pacing-induced cardiomyopathy, defined as a new diagnosis of systolic heart failure or a left ventricular ejection fraction &lt;50%, occurring from the index hospitalization through December 2024, after excluding other etiologies of heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The median age of the study population was 73.8 years (\u00b115). Baseline left ventricular ejection fraction was similar between groups (LP: 63\u00b17 versus TVP: 64\u00b18). During a median follow-up period of 2.4 years, 422 incident cases of PCM occurred. Incidence rates of pacing-induced cardiomyopathy were comparable (LP: 7.6% versus TVP: 8.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.187), including in patients with pacing indications of complete heart block or atrioventricular nodal ablation (LP: 10.3% versus TVP: 10.4%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.948). The mean drop in left ventricular ejection fraction was comparable between both groups; however, patients with LP were less likely to undergo cardiac resynchronization therapy upgrade compared with those with TVP (LP: 9.7% versus TVP: 17.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The incidence and characteristics of pacing-induced cardiomyopathy are similar between LP and TVP. However, patients with LP are less likely to undergo cardiac resynchronization therapy upgrade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.013800","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:00:11Z","timestamp":1753434011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3532-4171","authenticated-orcid":true,"given":"Favour E.","family":"Markson","sequence":"first","affiliation":[{"name":"Division of Cardiology, Jefferson Health-Einstein Hospital, Philadelphia, PA (F.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-2000","authenticated-orcid":true,"given":"Temidayo A.","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Jefferson Health-Einstein Hospital, Philadelphia, PA (F.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4857","authenticated-orcid":true,"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia (D.S.F., R.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-7247","authenticated-orcid":true,"given":"Robert D.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia (D.S.F., R.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.01.040"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.05.196"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipej.2016.02.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.889741"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.10.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511643"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14814"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15925"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15944"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.05.022"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooad035"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.08.052"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.02.025"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2024.07.008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1427"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01014.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/2772432816666210901111616"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.09.027"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43953-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-019-00602-2"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-015-0707-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.003564"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007809"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.013070"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000855"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.03.1538"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2020.10.003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab767"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300080"},{"key":"e_1_3_3_31_2","unstructured":"Case Studies & Publications \u2013 TriNetX. 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