{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:30:37Z","timestamp":1780551037193,"version":"3.54.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiac radioablation is emerging as a treatment modality for refractory ventricular tachycardia. This study aimed to evaluate the effects of radiation on the coronary arteries in a swine model of proton beam cardiac radioablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Eighteen swine underwent single-fraction 30 to 40 Gy pencil-beam scanning proton therapy targeting the left ventricle and were euthanized 12 to 40 weeks later. Treatment planning was performed without restricting the dose to the coronary arteries. The maximum point dose (D\n                      <jats:sub>max<\/jats:sub>\n                      ) to the epicardial coronary arteries was calculated. In secondary analyses, the mean (D\n                      <jats:sub>mean<\/jats:sub>\n                      ) and minimum dose received by the highest irradiated 0.01 cm\n                      <jats:sup>3<\/jats:sup>\n                      (D\n                      <jats:sub>0.01<\/jats:sub>\n                      ) of each coronary artery were also calculated. Coronary artery segments were harvested from the D\n                      <jats:sub>max<\/jats:sub>\n                      sites for histological analysis, and the D\n                      <jats:sub>max<\/jats:sub>\n                      was correlated with stenosis severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Ninety-six coronary arteries were analyzed. No stenoses were observed by computed tomography imaging preirradiation. By histological analysis posteuthanasia, 25\/96 (26%) coronaries sampled at their D\n                      <jats:sub>max<\/jats:sub>\n                      sites had \u226575% stenosis. The median D\n                      <jats:sub>max<\/jats:sub>\n                      was 4.7 Gy for the &lt;75% stenosis group and 29.7 Gy for the \u226575% stenosis group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). The AUC-ROC for the association between D\n                      <jats:sub>max<\/jats:sub>\n                      and stenosis \u226575% was 92.2%. A D\n                      <jats:sub>max<\/jats:sub>\n                      value of 20.1 Gy best predicted stenosis \u226575%, with sensitivity 92.3% and specificity 87.1%. The AUC-ROCs for the associations of D\n                      <jats:sub>mean<\/jats:sub>\n                      and D\n                      <jats:sub>0.01<\/jats:sub>\n                      with stenosis \u226575% were 84.8% and 91.6%, respectively. In histopathologic analysis, intimal hyperplasia was the most common coronary artery abnormality at the D\n                      <jats:sub>max<\/jats:sub>\n                      sites, and it was present in 61.5% of all arteries and in 93.9% of arteries with D\n                      <jats:sub>max<\/jats:sub>\n                      \u226520 Gy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      In this preclinical model of proton beam cardiac radioablation, coronary stenoses occurred in a dose-dependent manner, with D\n                      <jats:sub>max<\/jats:sub>\n                      showing the closest correlation with stenosis \u226575%. These data provide for the first time a framework for dose constraint considerations for the coronary arteries during treatment planning for cardiac radioablation and thoracic malignancy radiation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.013995","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T10:01:11Z","timestamp":1766656871000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Dose-Dependent Effects of Radiation on the Coronary Arteries: Results From a Preclinical Model of Single-Fraction Proton Beam Cardiac Radioablation"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-8726","authenticated-orcid":true,"given":"Tatsuhiko","family":"Hirao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.H., M.E.R., T.K., A.L., S.J.A., 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K.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Mayo Clinic, Rochester, MN (L.K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-2243","authenticated-orcid":true,"given":"Naomi M.","family":"Gades","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Mayo Clinic, Scottsdale, AZ (N.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-5313","authenticated-orcid":true,"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.H., M.E.R., T.K., A.L., S.J.A., K.C.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-5536","authenticated-orcid":true,"given":"Samuel J.","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Department of 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