{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:16Z","timestamp":1787068396944,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) can generate low-intensity catheter-tissue interface heating. Recently, a large-focal PFA catheter able to measure the tip-tissue interface temperature has become available. Accordingly, we aimed to characterize the electrode tip-tissue interface temperature dynamics during PFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A retrospective single-center study evaluated PFA lesions in 41 consecutive patients undergoing atrial fibrillation ablation using the lattice-tip catheter. Lesions were grouped by anatomic location with interface temperatures measured via catheter tip thermocouples. The association of predictors with lesion temperatures was evaluated with a mixed-effects model. An analysis of lesion dimensions and interface temperatures was also performed in swine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 41 patients, 2779 pulse field lesions were analyzed. Mean peak temperature was 41.7\u00b12.2\u2009\u00b0C (range, 37.2\u2009\u00b0C\u201352.8\u2009\u00b0C) and average temperature was 39.5\u00b11.4\u2009\u00b0C (range, 36.4\u2009\u00b0C\u201346.9\u2009\u00b0C). Temperatures exceeded 50\u2009\u00b0C in 10 of 2779 (0.4%) lesions, most often in the anterosuperior left superior pulmonary vein (5\/10). Univariate analysis showed peak temperature was positively associated with previous lesion temperature (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =0.65 [95% CI, 0.63\u20130.67];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and had weak associations with time between lesions (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =\u22120.15 [\u22120.19 to \u22120.11];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and percentage impedance drop (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =0.20 [95% CI, 0.16\u20130.23];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Even after multivariable analysis, the peak temperature remained significantly lowest at the right carina (39.7\u2009\u00b0C), anterosuperior right superior pulmonary vein (40.9\u2009\u00b0C), and right superior pulmonary vein roof (40.5\u2009\u00b0C) locations. Swine demonstrated a moderately strong association between lesion depth with peak temperature (\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      =0.53 [95% CI, 0.20\u20130.75];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.003) and average temperature (\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      =0.49 [95% CI, 0.16\u20130.73];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Lattice-tip temperatures during PFA vary substantially, with right superior pulmonary vein sites often demonstrating a blunted temperature response compared with other sites. Peak and average temperatures correlated with lesion depth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.014310","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:00:20Z","timestamp":1776675620000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Variability in Tissue Interface Temperature During Pulse Field Atrial Ablation: Implications for Real-Time Contact Assessment"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-4447","authenticated-orcid":true,"given":"John R.","family":"Power","sequence":"first","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-1690","authenticated-orcid":true,"given":"Keita","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-1408","authenticated-orcid":true,"given":"Masaya","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0931-7704","authenticated-orcid":true,"given":"Srinivas","family":"Dukkipati","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6826-8877","authenticated-orcid":true,"given":"Daniel R.","family":"Musikantow","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-9931","authenticated-orcid":true,"given":"William","family":"Whang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-0356","authenticated-orcid":true,"given":"Joshua","family":"Lampert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Maan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7066-7108","authenticated-orcid":true,"given":"Maryam","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Banai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-4608","authenticated-orcid":true,"given":"Connor P.","family":"Oates","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Krishna Reddy","family":"Seemala","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-4993","authenticated-orcid":true,"given":"Vivek Y","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-8372","authenticated-orcid":true,"given":"Jacob S.","family":"Koruth","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010086"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-024-01872-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad655.381"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux275"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.011110"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15813"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-024-01857-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012814"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007661"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.123.012717"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13095"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001094"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.04.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.05.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83683-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03022-6"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.125.014310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:00:46Z","timestamp":1780509646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.125.014310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1161\/CIRCEP.125.014310"],"URL":"https:\/\/doi.org\/10.1161\/circep.125.014310","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}