{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:28:12Z","timestamp":1792690092860,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Integration of catheter\u2013tissue contact force with pulsed field ablation (PFA) dosing is essential for achieving safe and durable lesion formation with contact force sensing catheters in ventricular models. However, data on the use of these catheters for atrial ablation remain limited. This study evaluated the procedural safety and 30-day lesion characteristics of atrial PFA delivered with the OMNYPULSE ablation catheter in a porcine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Twelve pigs were randomized to receive either 6 (\u00d76 or Group A) or 12 (\u00d712 or group B) PFA applications per ablation. Following 3-dimensional electroanatomic mapping, PFA was delivered to the right superior and inferior pulmonary veins, cavotricuspid isthmus, right atrial posterior wall, left atrial roof, and mitral annulus. Procedural safety was assessed acutely, and lesion characteristics were evaluated on 30-day histology. Maximum transmurality extent (MTE) was defined as &gt;80% of the lesion span exhibiting continuous endocardial-to-epicardial fibrosis within representative histological sections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Adequate catheter\u2013tissue contact was achieved during PFA delivery (contact force, 28\u00b115 g). No acute procedural complications were observed. At 30 days, PVs and right atrial sites (ie, cavotricuspid isthmus and right atrial posterior wall) demonstrated near-complete MTE regardless of PFA dosing. In contrast, MTE was significantly lower at the mitral annulus and LA roof compared with other sites (44\u00b130% and 21\u00b126%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Increasing the number of PFA applications (\u00d712) resulted in a remarkable improvement in MTE at these locations, with MTE increases of up to 68% compared with \u00d76 dosing at these sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Atrial PFA using the OMNYPULSE catheter was feasible and safe in a porcine model. However, lesion transmurality varied by atrial location and was dose-dependent at select sites, underscoring the need for site-specific PFA dosing strategies. Further studies are warranted to define optimal PFA parameters for consistent atrial lesion formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.014473","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:00:30Z","timestamp":1775034030000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Chronic Atrial Lesion Formation With a Large-Tip, Contact-Force-Sensing Multipolar Pulsed Field Ablation Catheter: Effect of Application Number in a Porcine Beating Heart Model"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":true,"given":"Luigi","family":"Di Biase","sequence":"first","affiliation":[{"name":"Department of Cardiology, Montefiore Medical Center, Bronx, NY (L.D.B., J.M., F.Z., D.Y., A.L., X.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-5925","authenticated-orcid":true,"given":"Jacopo","family":"Marazzato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Montefiore Medical Center, Bronx, NY (L.D.B., J.M., F.Z., D.Y., A.L., X.Z.)."},{"name":"Electrophysiology and Cardiac Pacing Unit, Humanitas Mater Domini, Castellanza, Varese, Italy (J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-3380","authenticated-orcid":true,"given":"Marco","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Monzino Hospital Milan, Milano, Italy (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-8843","authenticated-orcid":true,"given":"Fengwei","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Montefiore Medical Center, Bronx, NY (L.D.B., J.M., F.Z., D.Y., A.L., X.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9394-293X","authenticated-orcid":true,"given":"Taylor","family":"Spangler","sequence":"additional","affiliation":[{"name":"Bayside Preclinical Services Inc, Dixon (T. Spangler)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-8660","authenticated-orcid":true,"given":"Rahul","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Loma Linda University Heart Institute (R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-573X","authenticated-orcid":true,"given":"Jonathan","family":"Hsu","sequence":"additional","affiliation":[{"name":"University of California, San Diego (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1912-3184","authenticated-orcid":true,"given":"Assaf","family":"Govari","sequence":"additional","affiliation":[{"name":"Biosense Webster, Irvine, CA (A.G., A.A., K.O., T. Sharma, P.P., C.B., T.T., Q.C., W.M.)."},{"name":"Biosense Webster, Yokne\u2019am, Israel (A.G., A.A., K.O., T. Sharma, P.P., C.B., T.T., Q.C., W.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5439-357X","authenticated-orcid":true,"given":"Andreas","family":"Altman","sequence":"additional","affiliation":[{"name":"Biosense Webster, Irvine, CA (A.G., A.A., K.O., T. Sharma, P.P., C.B., T.T., Q.C., W.M.)."},{"name":"Biosense Webster, Yokne\u2019am, Israel (A.G., A.A., K.O., T. Sharma, P.P., C.B., T.T., Q.C., W.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5767-848X","authenticated-orcid":true,"given":"Kevin","family":"Okarski","sequence":"additional","affiliation":[{"name":"Biosense Webster, Irvine, CA (A.G., A.A., K.O., T. Sharma, P.P., C.B., T.T., Q.C., W.M.)."},{"name":"Biosense Webster, Yokne\u2019am, Israel (A.G., A.A., K.O., T. 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Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.125.014473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:04:37Z","timestamp":1776794677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.125.014473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1161\/CIRCEP.125.014473"],"URL":"https:\/\/doi.org\/10.1161\/circep.125.014473","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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