{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:55:35Z","timestamp":1793134535297,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Remapping studies have evaluated chronic lesion durability of the first-generation pentaspline pulsed field ablation (PFA) catheter that did not have integrated electroanatomical mapping. By invasive remapping, this first-in-human study evaluated the durability of lesions facilitated by the integration of the navigation-enabled pentaspline PFA catheter and mapping system in patients with atrial fibrillation.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n The\n NAVIGATE-PF Phase 2<\/jats:italic>\n trial evaluated the second-generation, mapping-integrated pentaspline PFA catheter. Lesion durability was assessed by invasive remapping 60 days post index procedure.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n After index ablation in 20 patients with the pentaspline PFA catheter, remaps were performed 60 days later in 17 patients, demonstrating a high rate of lesion durability in the pulmonary veins (95%) and posterior wall (86%).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n By facilitating real-time visualization of catheter positioning and acute lesion estimation through tags, the second-generation map-and-ablate pentaspline PFA catheter and integrated mapping system may enhance procedural success.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION:<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT06175234.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circep.125.014477","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:00:41Z","timestamp":1775034041000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Lesion Durability of the Second Generation Pentaspline Pulsed Field Ablation Catheter\n NAVIGATE-PF<\/i>\n Phase 2 Results"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"nct06175234","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-4993","authenticated-orcid":true,"given":"Vivek Y.","family":"Reddy","sequence":"first","affiliation":[{"name":"Homolka Hospital, Prague, Czech Republic (V.Y.R., J.P., M.F., P.N.)."},{"name":"Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, NY 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