{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:18:50Z","timestamp":1794107930280,"version":"4.8.0"},"reference-count":156,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Recent meta-analyses of randomized controlled trials have raised concerns that treatment with omega-3 fatty acids may increase the risk of atrial fibrillation (AF). However, these meta-analyses included at most 8 trials. The aim of this current meta-analysis was to expand the search by including other eligible omega-3 randomized controlled trials with AF incidence data, incorporating both published and unpublished data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Eligible studies were randomized controlled trials investigating daily doses of \u2265500 mg\/d of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Additional inclusion criteria included \u226512 months of treatment with EPA\/DHA, participants \u226550 years of age, and, where possible, the absence of known AF\/atrial flutter at baseline. The primary outcome was the occurrence of new-onset AF. Our primary hypothesis was that risk for AF would simultaneously depend on both omega-3 dose (above or below 1500 mg\/d) and background cardiovascular disease risk status, and that their combined impact on AF risk would be synergistic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 35 randomized controlled trials (37 data sets; n=114\u2009592) were included in this meta-analysis. Only studies including patients at high-risk for cardiovascular disease who were treated with high-doses of EPA\/DHA (&gt;1500 mg\/d) showed a statistically significant increase in AF risk with a pooled odds ratio (OR) of 1.43 (95% CI, 1.14\u20131.79) and an absolute risk difference of 0.8% (0.40%\u20131.1%). None of the other 3 groups showed statistically significant levels of AF risk (odds ratios, 1.07 [high risk\u2013low dose], 1.06 [low risk\u2013low dose], and 1.03 [low risk\u2013high dose]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This meta-analysis suggests that high-dose EPA\/DHA treatment is associated with an increased risk of AF in patients at high cardiovascular disease risk, whereas low-dose EPA\/DHA does not appear to increase AF risk, even in high-risk populations. Further prospective studies are needed to evaluate any potential increased risk of higher doses balanced against potential benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.125.014785","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:01:07Z","timestamp":1785229267000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114\u2009592 Individuals"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-2979","authenticated-orcid":true,"given":"Nada R.","family":"Abuknesha","sequence":"first","affiliation":[{"name":"Fatty Acid Research Institute, Sioux Falls, SD (N.R.A., J.H.O.K., N.L.T., W.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-5822","authenticated-orcid":true,"given":"James H","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Fatty Acid Research Institute, Sioux Falls, SD (N.R.A., J.H.O.K., N.L.T., W.S.H.)."},{"name":"Saint Luke\u2019s Mid America Heart Institute &amp; 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