{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:49:38Z","timestamp":1782460178126,"version":"3.54.5"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Genom Precis Med."],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1161\/circgen.117.002151","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T15:10:38Z","timestamp":1539616238000},"source":"Crossref","is-referenced-by-count":35,"title":["Variants in<i>NKX2-5<\/i>and<i>FLNC<\/i>Cause Dilated Cardiomyopathy and Sudden Cardiac Death"],"prefix":"10.1161","volume":"11","author":[{"given":"Gardar","family":"Sveinbjornsson","sequence":"first","affiliation":[{"name":"deCODE genetics\/Amgen, Inc, Reykjavik, Iceland (G.S., E.F.O., R.B.T., O.B.D., A.H."},{"name":"School of Engineering and Natural Sciences (G.S., D.F.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva F.","family":"Olafsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics\/Amgen, Inc, Reykjavik, Iceland (G.S., E.F.O., R.B.T., O.B.D., A.H."},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa B.","family":"Thorolfsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics\/Amgen, Inc, Reykjavik, Iceland (G.S., E.F.O., R.B.T., O.B.D., A.H."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur B.","family":"Davidsson","sequence":"additional","affiliation":[{"name":"deCODE genetics\/Amgen, Inc, Reykjavik, Iceland (G.S., E.F.O., R.B.T., O.B.D., A.H."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Helgadottir","sequence":"additional","affiliation":[{"name":"deCODE genetics\/Amgen, Inc, Reykjavik, Iceland (G.S., E.F.O., R.B.T., O.B.D., A.H."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalbjorg","family":"Jonasdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslaug","family":"Jonasdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eythor","family":"Bjornsson","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brynjar O.","family":"Jensson","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudny A.","family":"Arnadottir","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallfridur","family":"Kristinsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur S.","family":"Stephensen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Children\u2019s Hospital Reykjavik, Iceland (S.S.S., G.O.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gylfi","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Children\u2019s Hospital Reykjavik, Iceland (S.S.S., G.O.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Gudbjartsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"},{"name":"Department of Cardiothoracic Surgery (T.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil L.","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Department of Family Medicine (E.L.S.), University of Iceland, Reykjavik"},{"name":"Department of Development, Primary Health Care of the Capital Area, Reykjavik, Iceland (E.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Andersen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"},{"name":"Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland (K.A., R.D., D.O.A., G.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland (K.A., R.D., D.O.A., G.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Arnar","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"},{"name":"Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland (K.A., R.D., D.O.A., G.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingileif","family":"Jonsdottir","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"},{"name":"Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik (I.J.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnur","family":"Thorsteinsdottir","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sulem","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudmundur","family":"Thorgeirsson","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"},{"name":"Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland (K.A., R.D., D.O.A., G.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Gudbjartsson","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"School of Engineering and Natural Sciences (G.S., D.F.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilma","family":"Holm","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Stefansson","sequence":"additional","affiliation":[{"name":"Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.)"},{"name":"Faculty of Medicine (E.F.O., E.B., H.K., T.G., K.A., D.O.A., I.J., U.T., G.T., K.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.08.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62862"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00172-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65738-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.06.022"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.962050"},{"key":"e_1_3_3_9_2","first-page":"3845","article-title":"Cardiac troponin T mutations promote life-threatening arrhythmias.","volume":"118","author":"Fiset C","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.167"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181f2481f"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv253"},{"key":"e_1_3_3_13_2","first-page":"43","article-title":"Genetics and genetic testing of dilated cardiomyopathy: a new perspective.","volume":"15","author":"Mestroni L","year":"2013","journal-title":"Discov Med"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq271"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.115"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000057"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.2029"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/431959"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1054-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.05.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22942"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6326"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw093"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1153"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.011207"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611063151902"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.08.033"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2610"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1242\/dev.119.3.969","article-title":"Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.","volume":"119","author":"Lints TJ","year":"1993","journal-title":"Development"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.171835"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi300849c"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.86"},{"key":"e_1_3_3_34_2","first-page":"Unit7.20","article-title":"Predicting functional effect of human missense mutations using PolyPhen-2.","volume":"7","author":"Adzhubei I","year":"2013","journal-title":"Curr Protoc Hum Genet"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.06.004"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21345"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8154"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0917-3"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(01)00072-6"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.10.008"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm271"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.03.009"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23349"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.021"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823dc51e"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.927"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302575110"}],"container-title":["Circulation: Genomic and Precision Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T01:14:35Z","timestamp":1662254075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGEN.117.002151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1161\/CIRCGEN.117.002151"],"URL":"https:\/\/doi.org\/10.1161\/circgen.117.002151","relation":{},"ISSN":["2574-8300","2574-8300"],"issn-type":[{"value":"2574-8300","type":"print"},{"value":"2574-8300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}