{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:57:27Z","timestamp":1792814247847,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Integration of systems-level biomolecular information with electronic health records has led to recent interest in the glycoprotein acetyls (GlycA) biomarker\u2014a serum- or plasma-derived nuclear magnetic resonance spectroscopy signal that represents the abundance of circulating glycated proteins. GlycA predicts risk of diverse outcomes, including cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality; however, the underlying detailed associations of GlycA\u2019s morbidity and mortality risk are currently unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used 2 population-based cohorts totaling 11 861 adults from the Finnish general population to test for an association with 468 common incident hospitalization and mortality outcomes during an 8-year follow-up. Further, we utilized 900 angiography patients to test for GlycA association with mortality risk and potential utility for mortality risk discrimination during 12-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>New associations with GlycA and incident alcoholic liver disease, chronic renal failure, glomerular diseases, chronic obstructive pulmonary disease, inflammatory polyarthropathies, and hypertension were uncovered, and known incident disease associations were replicated. GlycA associations for incident disease outcomes were in general not attenuated when adjusting for hsCRP (high-sensitivity C-reactive protein). Among 900 patients referred to angiography, GlycA had hazard ratios of 4.87 (95% CI, 2.45\u20139.65) and 5.00 (95% CI, 2.38\u201310.48) for 12-year risk of mortality in the fourth and fifth quintiles by GlycA levels, demonstrating its prognostic potential for identification of high-risk individuals. When modeled together, both hsCRP and GlycA were attenuated but remained significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>GlycA was predictive of myriad incident diseases across many major internal organs and stratified mortality risk in angiography patients. Both GlycA and hsCRP had shared and independent contributions to mortality risk, suggesting chronic inflammation as an etiological factor. GlycA may be useful in improving risk prediction in specific disease settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.118.002234","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T11:02:34Z","timestamp":1546858954000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients"],"prefix":"10.1161","volume":"11","author":[{"given":"Johannes","family":"Kettunen","sequence":"first","affiliation":[{"name":"Computational Medicine, Biocenter Oulu, University of Oulu, Finland (J.K., O.A., M.A.-K.)"},{"name":"National Institute for Health and Welfare, Helsinki, Finland (J.K., A.S.H., V.S., S.M., M.P.)"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (J.K., M.A.-K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Cambridge Baker Systems Genomics Initiative (S.C.R., M.I.)."},{"name":"Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (S.C.R., M.I.)."},{"name":"Department of Public Health and Primary Care, University of Cambridge, United Kingdom (S.C.R., M.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Anufrieva","sequence":"additional","affiliation":[{"name":"Computational Medicine, Biocenter Oulu, University of Oulu, Finland (J.K., O.A., M.A.-K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo-Pekka","family":"Lyytik\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., J.H., T.L.)"},{"name":"Department of Clinical Chemistry, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (L.-P.L., J.H., T.L.)"},{"name":"Department of Cardiology, Heart Center, Tampere University Hospital, Finland (L.-P.L., J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Hernesniemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., J.H., T.L.)"},{"name":"Department of Clinical Chemistry, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (L.-P.L., J.H., T.L.)"},{"name":"Department of Cardiology, Heart Center, Tampere University Hospital, Finland (L.-P.L., J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka J.","family":"Karhunen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Fimlab Laboratories, Tampere, Finland (P.J.K.)"},{"name":"Department of Forensic Medicine, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (P.J.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Kuukasj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (P.K., J.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Laurikka","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (P.K., J.L.)"},{"name":"Department of Cardiothoracic Surgery, Heart Center, Tampere University Hospital, Finland (J.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (M.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., J.H., T.L.)"},{"name":"Department of Clinical Chemistry, Tampere University Hospital, Finnish Cardiovascular Research Center Tampere, University of Tampere, Finland.  (L.-P.L., J.H., T.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki S.","family":"Havulinna","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland (J.K., A.S.H., V.S., S.M., M.P.)"},{"name":"Institute for Molecular Medicine, University of Helsinki, Finland. (A.S.H., M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veikko","family":"Salomaa","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland (J.K., A.S.H., V.S., S.M., M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland (J.K., A.S.H., V.S., S.M., M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ala-Korpela","sequence":"additional","affiliation":[{"name":"Computational Medicine, Biocenter Oulu, University of Oulu, Finland (J.K., O.A., M.A.-K.)"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (J.K., M.A.-K.)"},{"name":"Population Health Science, Bristol Medical School, University of Bristol, United Kingdom (M.A.-K.)"},{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, United Kingdom (M.A.-K.)"},{"name":"Systems Epidemiology Lab, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.A.-K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Perola","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland (J.K., A.S.H., V.S., S.M., M.P.)"},{"name":"Institute for Molecular Medicine, University of Helsinki, Finland. 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