{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:50Z","timestamp":1787018030897,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66\u2009643 subjects (27\u2009708 with CAD and 24\u2009259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117\u2009787 subjects (16\u2009694 with CAD and 11\u2009537 with T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.119.002769","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T23:41:25Z","timestamp":1597362085000},"source":"Crossref","is-referenced-by-count":9,"title":["Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-1398","authenticated-orcid":true,"given":"Natalie R.","family":"van Zuydam","sequence":"first","affiliation":[{"name":"Pat Macpherson Center for Pharmacogenetics &amp; Pharmacogenomics, Cardiovascular &amp; Diabetes Medicine (N.R.v.Z., C.N.A.P.), School of Medicine, University of Dundee."},{"name":"Oxford Center for Diabetes, Endocrinology &amp; Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom."},{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-6598","authenticated-orcid":true,"given":"Claes","family":"Ladenvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Diabetes &amp; Endocrinology, Lund University Diabetes Center, Malm\u00f6, Sweden (C.L., L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-9994","authenticated-orcid":true,"given":"Benjamin F.","family":"Voight","sequence":"additional","affiliation":[{"name":"Department of Systems Pharmacology &amp; Translational Therapeutics (B.F.V.)"},{"name":"Department of Genetics (B.F.V.)"},{"name":"Institute for Translational Medicine &amp; Therapeutics (B.F.V.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-3585","authenticated-orcid":true,"given":"Rona J.","family":"Strawbridge","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden (R.J.S., A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-2421","authenticated-orcid":true,"given":"Juan","family":"Fernandez-Tajes","sequence":"additional","affiliation":[{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0510-4792","authenticated-orcid":true,"given":"N. William","family":"Rayner","sequence":"additional","affiliation":[{"name":"Oxford Center for Diabetes, Endocrinology &amp; Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom."},{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."},{"name":"Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom (N.W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Oxford Center for Diabetes, Endocrinology &amp; Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom."},{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubha","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Oxford Center for Diabetes, Endocrinology &amp; Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom."},{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymia","family":"Vlachopoulou","sequence":"additional","affiliation":[{"name":"Transplantation Laboratory, Haartman Institute (E.V.), University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-4021","authenticated-orcid":true,"given":"Anuj","family":"Goel","sequence":"additional","affiliation":[{"name":"Wellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom."},{"name":"Division of Cardiovascular Medicine (A.G., H.W.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E.","family":"Kleber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester (C.P.N., N.J.S.)."},{"name":"NIHR Leicester Biomedical Research Center, Glenfield Hospital, Leicester, United Kingdom (C.P.N., N.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-8571","authenticated-orcid":true,"given":"Lydia Coulter","family":"Kwee","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute, Duke University, Durham, NC (L.C.K., S.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-6569","authenticated-orcid":true,"given":"T\u00f5nu","family":"Esko","sequence":"additional","affiliation":[{"name":"Estonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. 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