{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:36:15Z","timestamp":1792640175117,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Brugada syndrome (BrS) is associated with mutations in the cardiac sodium channel gene,\n              <jats:italic>SCN5A.<\/jats:italic>\n              However, genetic studies of patients with BrS with arrhythmic events have been limited. We sought to compare various clinical, ECG, and electrophysiological parameters according to\n              <jats:italic>SCN5A<\/jats:italic>\n              genotype in a large cohort of BrS probands with first arrhythmic event.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Survey on Arrhythmic Events in Brugada Syndrome is a survey of 10 Western and 4 Asian countries, gathering 678 patients with BrS with first arrhythmic event. Only probands were included, and\n              <jats:italic>SCN5A<\/jats:italic>\n              genotype adjudicated. Patients without appropriate genetic data were excluded. Associations of genotype with clinical features were analyzed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The study group comprised 392 probands: 92 (23.5%)\n              <jats:italic>SCN5A+<\/jats:italic>\n              (44 pathogenic\/likely pathogenic [P\/LP] and 48 variants of unknown significance) and 300 (76.5%)\n              <jats:italic>SCN5A\u2212.<\/jats:italic>\n              <jats:italic>SCN5A<\/jats:italic>\n              missense variants and the patients hosting them were similar regardless of adjudication. A higher proportion of patients with P\/LP were pediatric (&lt;16 years) compared with\n              <jats:italic>SCN5A\u2212<\/jats:italic>\n              (11.4% versus 3%,\n              <jats:italic>P<\/jats:italic>\n              =0.023). The proportion of females was higher among patients with P\/LP compared with\n              <jats:italic>SCN5A<\/jats:italic>\n              \u2212 (18.2% versus 6.3%,\n              <jats:italic>P<\/jats:italic>\n              =0.013). P\/LP probands were more likely to have a family history of sudden cardiac death compared with\n              <jats:italic>SCN5A<\/jats:italic>\n              \u2212 (41.9% versus 16.8%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). A higher proportion of patients with P\/LP were White compared with\n              <jats:italic>SCN5A\u2212<\/jats:italic>\n              (87.5% versus 47%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Ethnicity (odds ratio, 5.41 [2.8\u201311.19],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and family history of sudden cardiac death (odds ratio, 2.73 [1.28\u20135.82],\n              <jats:italic>P<\/jats:italic>\n              =0.009) were independent variables associated with P\/LP genotype following logistic regression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              The genetic basis of BrS has a complex relationship with gender, ethnicity, and age. Probands hosting a P\/LP variant tended to experience their first arrhythmic event at a younger age and to have events triggered by fever compared with patients with\n              <jats:italic>SCN5A\u2212<\/jats:italic>\n              . In addition, they were more likely to be White and to have family history of sudden cardiac death. Among females, a P\/LP variant suggests an increased risk of being symptomatic. This association should be further studied on an ethnically specific basis in large prospectively collected international cohorts.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgen.120.003222","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T09:00:19Z","timestamp":1630400419000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Genotype-Phenotype Correlation of\n            <i>SCN5A<\/i>\n            Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-4101","authenticated-orcid":true,"given":"Anat","family":"Milman","sequence":"first","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center, Tel Hashomer, Israel (A. Milman)."},{"name":"Sackler School of Medicine, Tel Aviv University, Israel (A. Milman, A.H., B.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-4101","authenticated-orcid":true,"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Cardiovascular Clinical Academic Group, St George\u2019s, University of London &amp; St. George\u2019s University Hospitals NHS Foundation Trust, United Kingdom (E.R.B., B.G., D.C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-4101","authenticated-orcid":true,"given":"Belinda","family":"Gray","sequence":"additional","affiliation":[{"name":"Cardiovascular Clinical Academic Group, St George\u2019s, University of London &amp; St. George\u2019s University Hospitals NHS Foundation Trust, United Kingdom (E.R.B., B.G., D.C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-3170","authenticated-orcid":true,"given":"David C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Cardiovascular Clinical Academic Group, St George\u2019s, University of London &amp; St. George\u2019s University Hospitals NHS Foundation Trust, United Kingdom (E.R.B., B.G., D.C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-5452","authenticated-orcid":true,"given":"Antoine","family":"Andorin","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Service de Cardiologie, CHU de Nantes, France (A.A., J.-B.G., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3145","authenticated-orcid":true,"given":"Aviram","family":"Hochstadt","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel (A. Milman, A.H., B.B.)."},{"name":"Department of Cardiology, Tel-Aviv Sourasky Medical Center, Israel (A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6961-2131","authenticated-orcid":true,"given":"Jean-Baptiste","family":"Gourraud","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Service de Cardiologie, CHU de Nantes, France (A.A., J.-B.G., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan (S.M., Y.T., K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-996X","authenticated-orcid":true,"given":"Yoshihide","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan (S.M., Y.T., K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-7636","authenticated-orcid":true,"given":"Jimmy","family":"JM Juang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Division of Cardiology, National Taiwan University Hospital &amp; University College of Medicine, Taipei (J.J.M.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, College of Medicine, The Catholic University of Korea, Seoul, Korea (S.-H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-7927","authenticated-orcid":true,"given":"Tsukasa","family":"Kamakura","sequence":"additional","affiliation":[{"name":"Division of Arrhythmia and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan (T.K., T.A., K.F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Takeshi","family":"Aiba","sequence":"additional","affiliation":[{"name":"Division of Arrhythmia and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan (T.K., T.A., K.F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Pieter G.","family":"Postema","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical &amp; Experimental Cardiology, the Netherlands (P.G.P., Y.M., A.A.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1858-0923","authenticated-orcid":true,"given":"Yuka","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical &amp; Experimental Cardiology, the Netherlands (P.G.P., Y.M., A.A.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Isabelle","family":"Denjoy","sequence":"additional","affiliation":[{"name":"Service de Cardiologie et CNMR Maladies Cardiaques H\u00e9r\u00e9ditaires Rares, H\u00f4pital Bichat &amp; Universit\u00e9 Paris Diderot, Sorbonne, France (I.D., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-3398","authenticated-orcid":true,"given":"Carla","family":"Giustetto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Torino, Department of Medical Sciences, Citt\u00e0 della Salute e della Scienza Hospital, Italy (C.G., F.G.)."},{"name":"Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium (G.C., P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Giulio","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-9321","authenticated-orcid":true,"given":"Zhengrong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Xiamen University, Fujian, China (Z.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Sarquella-Brugada","sequence":"additional","affiliation":[{"name":"Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit Cardiology, Department Hospital Sant Joan de D\u00e9u, Barcelona - Universitat de Barcelona, Spain (G.S.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-2172","authenticated-orcid":true,"given":"Andrea","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy (A. Mazzanti, S.G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-9637","authenticated-orcid":true,"given":"Camilla H.","family":"Jespersen","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"The Heart Centre, Copenhagen University Hospital, Denmark (C.H.J., J.T.-H.)."},{"name":"Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark (C.H.J., J.T.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6393","authenticated-orcid":true,"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain (E.A., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-3032","authenticated-orcid":true,"given":"Ramon","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Center, University of Girona-IDIBGI, Spain (R.B.)."},{"name":"Medical Science Department, School of Medicine, University of Girona, Spain (R.B.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-8617","authenticated-orcid":true,"given":"Leonardo","family":"Calo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Policlinico Casilino, Roma, Italy (L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0392","authenticated-orcid":true,"given":"Domenico","family":"Corrado","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padova, Italy (D.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-6074","authenticated-orcid":true,"given":"Ruben","family":"Casado-Arroyo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasme University Hospital, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium (R.C.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-2131","authenticated-orcid":true,"given":"Giuseppe","family":"Allocca","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy (G.A., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-8529","authenticated-orcid":true,"given":"Masahiko","family":"Takagi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Arrhythmia, Kansai Medical University Medical Center, Moriguchi, Japan (M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Delise","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy (G.A., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-8302","authenticated-orcid":true,"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain (E.A., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"The Heart Centre, Copenhagen University Hospital, Denmark (C.H.J., J.T.-H.)."},{"name":"Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark (C.H.J., J.T.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-0288","authenticated-orcid":true,"given":"Silvia G.","family":"Priori","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy (A. Mazzanti, S.G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Christian","family":"Veltmann","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology &amp; Angiology, Hannover Medical School, Hannover, Germany (C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-5680","authenticated-orcid":true,"given":"Gan-Xin","family":"Yan","sequence":"additional","affiliation":[{"name":"Lankenau Medical Center, Wynnewood, PA (G.-X.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-6106","authenticated-orcid":true,"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium (G.C., P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Gaita","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Torino, Department of Medical Sciences, Citt\u00e0 della Salute e della Scienza Hospital, Italy (C.G., F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Antoine","family":"Leenhardt","sequence":"additional","affiliation":[{"name":"Service de Cardiologie et CNMR Maladies Cardiaques H\u00e9r\u00e9ditaires Rares, H\u00f4pital Bichat &amp; Universit\u00e9 Paris Diderot, Sorbonne, France (I.D., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Arthur A.M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical &amp; Experimental Cardiology, the Netherlands (P.G.P., Y.M., A.A.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo F.","family":"Kusano","sequence":"additional","affiliation":[{"name":"Division of Arrhythmia and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan (T.K., T.A., K.F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-5406","authenticated-orcid":true,"given":"Gi-Byoung","family":"Nam","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (G.-B.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Hirao","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan (S.M., Y.T., K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":true,"given":"Vincent","family":"Probst","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (E.R.B., D.C.J., A.A., J.-B.G., P.G.P., Y.M., A. Mazzanti, C.H.J., D.C., J.T.-H., S.G.P., A.A.M.W., V.P.)."},{"name":"Service de Cardiologie, CHU de Nantes, France (A.A., J.-B.G., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-2054","authenticated-orcid":true,"given":"Bernard","family":"Belhassen","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel (A. Milman, A.H., B.B.)."},{"name":"Heart Institute, Hadassah University Hospital, Jerusalem, Israel (B.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-j"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.037"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/32675"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.97"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035070"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2712"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz448"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13552"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005222"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.01.014"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.06.019"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.07.003"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000831"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur245"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.064"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887026"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153267.21278.8D"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01962-9"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.11.009"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00455.x"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027983"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00103"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.02.013"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032002.22105.7a"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00743.x"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-10-0221"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101058200"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.201805_34(3).20180302B"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2016.07.012"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.580811"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.119.002797"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","unstructured":"Makarawate P Glinge C Khongphatthanayothin A Walsh R Mauleekoonphairoj J Amnueypol M Prechawat S Wongcharoen W Krittayaphong R Anannab A et al. Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand. Heart Rhythm. 2020;17:2145\u20132153. doi: 10.1016\/j.hrthm.2020.06.027","DOI":"10.1016\/j.hrthm.2020.06.027"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12548"}],"container-title":["Circulation: Genomic and Precision Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCGEN.120.003222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:11:37Z","timestamp":1715562697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGEN.120.003222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1161\/CIRCGEN.120.003222"],"URL":"https:\/\/doi.org\/10.1161\/circgen.120.003222","relation":{},"ISSN":["2574-8300"],"issn-type":[{"value":"2574-8300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2020-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003222"}}