{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:59:48Z","timestamp":1789070388371,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              In Lamin A\/C (\n              <jats:italic>LMNA<\/jats:italic>\n              ) cardiomyopathy, atrial fibrillation (AF) commonly occurs before dilated cardiomyopathy, and the ability to predict its incidence is limited. We hypothesized that left atrial (LA) echocardiographic phenotyping can identify atrial myopathy and harbingers of AF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Echocardiograms from patients with pathogenic or likely pathogenic variants in\n              <jats:italic>LMNA<\/jats:italic>\n              (n=77) with and without reduced left ventricular ejection fraction (LVEF, &lt;50%) were compared to healthy individuals (n=70) and patients with Titin truncating variant cardiomyopathy\n              <jats:italic>(TTNtv<\/jats:italic>\n              ) (n=35) with similar LVEF, sex, and age distributions. Echocardiographic analysis, blinded to genotype, included strain and volumetric measures of left ventricular and atrial function. The primary outcome was incident AF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              At baseline, 43% of the patients with pathogenic or likely pathogenic\n              <jats:italic>LMNA<\/jats:italic>\n              variants had a history of AF, including 26% of those with LVEF \u226550%. Compared with healthy subjects, the patients with pathogenic or likely pathogenic\n              <jats:italic>LMNA<\/jats:italic>\n              variants and LVEF \u226550% had reduced LA contractile strain (\n              <jats:italic>LMNA<\/jats:italic>\n              , 11.8\u00b16.1% versus control, 15.0\u00b14.2%;\n              <jats:italic>P<\/jats:italic>\n              =0.003). Compared to LVEF-matched (\n              <jats:italic>TTNtv<\/jats:italic>\n              ) patients, the patients with pathogenic or likely pathogenic\n              <jats:italic>LMNA<\/jats:italic>\n              variants and LVEF &lt;50% displayed no difference in LA size, but a worse LA contractile dysfunction (6.4\u00b14.7% versus 12.6\u00b19.6%;\n              <jats:italic>P<\/jats:italic>\n              =0.02). Over a median follow-up of 2.8 (1.2\u20135.7) years, LA contractile strain was the only significant predictor of AF in multivariable Cox regression (hazard ratio, 4.0 [95% CI, 1.04\u201315.2]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              <jats:italic>LMNA<\/jats:italic>\n              cardiomyopathy is associated with early intrinsic atrial myopathy reflected by high AF prevalence and reduced LA contractile strain, even in the absence of LV dysfunction and LA dilation. Whether LA strain can be used as a monitoring strategy to detect and mitigate AF complications requires validation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgen.121.003480","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T19:38:51Z","timestamp":1671737931000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in\n            <i>Lamin A\/C<\/i>\n            Cardiomyopathy"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-2064","authenticated-orcid":true,"given":"Maxime","family":"Tremblay-Gravel","sequence":"first","affiliation":[{"name":"Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.T.-G., K.I., A.M.D., M.T.W., V.N.P.)."},{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada (M.T.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-335X","authenticated-orcid":true,"given":"Kenzo","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.T.-G., K.I., A.M.D., M.T.W., V.N.P.)."},{"name":"Cardiovascular Institute, Stanford University School of Medicine, CA (K.I., F.H., V.N.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kermshlise","family":"Picard","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (K.P., N.K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-5982","authenticated-orcid":true,"given":"Yumeko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital, Boston, MA (Y.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika M.","family":"Dries","sequence":"additional","affiliation":[{"name":"Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.T.-G., K.I., A.M.D., M.T.W., V.N.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Haddad","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Stanford University School of Medicine, CA (K.I., F.H., V.N.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-5421","authenticated-orcid":true,"given":"Neal K.","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (K.P., N.K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-3022","authenticated-orcid":true,"given":"Matthew T.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.T.-G., K.I., A.M.D., M.T.W., V.N.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5138-5559","authenticated-orcid":true,"given":"Victoria N.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Center for 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