{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:05:16Z","timestamp":1785272716052,"version":"3.55.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We performed a cross-sectional study in 11\u2009252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With &gt;30\u2009000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm\u2009Hg or more, or diastolic blood pressure of 85 mm\u2009Hg or more, or taking an antihypertensive drug.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32\u20132.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26\u20136.85) and 2.32 (95% CI, 0.86\u20133.78) mm\u2009Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgen.121.003612","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T18:35:16Z","timestamp":1654540516000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-2059","authenticated-orcid":true,"given":"Ryosuke","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan (R.F., Y.T., K.S.), Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"name":"Division of interactive Medical &amp; Healthcare Systems, Department of Integrated Health Sciences (R.F., T. Kondo), Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"name":"Institute for Biomedicine, Eurac Research (affiliated to the University of L\u00fcbeck), Bolzano\/Bozen, Italy (R.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-0201","authenticated-orcid":true,"given":"Asahi","family":"Hishida","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine (A.H., R.O., T.T., K.T., K.W.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-4837","authenticated-orcid":true,"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[{"name":"Public Health Informatics Unit, Department of Integrated Health Sciences (M.N.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-3949","authenticated-orcid":true,"given":"Yoshiki","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan (R.F., Y.T., K.S.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-9558","authenticated-orcid":true,"given":"Koji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan (R.F., Y.T., K.S.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-0841","authenticated-orcid":true,"given":"Takaaki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of interactive Medical &amp; Healthcare Systems, Department of Integrated Health Sciences (R.F., T. Kondo), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-6341","authenticated-orcid":true,"given":"Hiroaki","family":"Ikezaki","sequence":"additional","affiliation":[{"name":"Department of Comprehensive General Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (H.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-3237","authenticated-orcid":true,"given":"Megumi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan (M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-2501","authenticated-orcid":true,"given":"Rieko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine (A.H., R.O., T.T., K.T., K.W.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-744X","authenticated-orcid":true,"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine (A.H., R.O., T.T., K.T., K.W.), Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Shimoshikiryo","sequence":"additional","affiliation":[{"name":"Department of International Island &amp; Community Medicine, Kagoshima University Graduate School of Medical &amp; Dental Sciences, Kagoshima, Japan (I.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-368X","authenticated-orcid":true,"given":"Teruhide","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Epidemiology for Community Health &amp; Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan (T. 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