{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:44:22Z","timestamp":1792676662599,"version":"4.5.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>While GWAS (genome-wide association studies) have identified over 1000 obesity-associated loci, their functional impact on gene expression remains unclear. Moreover, many studies have not fully captured the genetic architecture of obesity in high-risk populations or considered the complexity of adiposity beyond traditional measures. To address these gaps, this study explores the genetic and transcriptomic pathways of obesity using diverse obesity phenotypes in a high-risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We analyzed genomic and whole-blood transcriptomic data from the CCHC (Cameron County Hispanic Cohort), performing GWAS on 13 obesity-related traits. Differential expression analysis was conducted for genes near GWAS-identified single nucleotide polymorphisms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;5\u00d710\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) followed by expression quantitative trait loci mapping and GWAS-expression quantitative trait loci colocalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      GWAS identified 486 trait associations, including 6 genome-wide significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;5\u00d710\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) loci, with 3 novel signals linked to abdominal subcutaneous adipose tissue, body fat percentage, and waist circumference. Among 3024 genes near these loci, 60 showed differential expression. Further expression quantitative trait loci analysis suggested 2 single nucleotide polymorphism-gene-trait relationships: rs543314376-\n                      <jats:italic toggle=\"yes\">MAPK11<\/jats:italic>\n                      , associated with subcutaneous adipose tissue volume in females, and rs963018484-\n                      <jats:italic toggle=\"yes\">PER1<\/jats:italic>\n                      , linked to body mass index in females. Both genes play key roles in obesity-related pathways, including inflammation and circadian rhythm regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This integrative genomic-transcriptomic analysis uncovers 2 novel candidate genes for obesity and underscores the critical need for involving all populations and comprehensive adiposity measures in obesity research. By expanding beyond body mass index in a Hispanic\/Latino population, we move closer to a deeper and more inclusive understanding of obesity\u2019s genetic architecture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.125.005298","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:00:37Z","timestamp":1777280437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Genomic and Transcriptomic Study Reveals\n                    <i>MAPK11<\/i>\n                    and\n                    <i>PER1<\/i>\n                    as Important Obesity Susceptibility Genes in a High-Risk Hispanic\/Latino Population"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-0739","authenticated-orcid":true,"given":"Daeeun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill (D.K., M.G.G., L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-9752","authenticated-orcid":true,"given":"Hannah G.","family":"Polikowsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-8239","authenticated-orcid":true,"given":"Heather M.","family":"Highland","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-2797","authenticated-orcid":true,"given":"Hung-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (H.-H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-3048","authenticated-orcid":true,"given":"Wanying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-4592","authenticated-orcid":true,"given":"Xinruo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline G.","family":"Gillman","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill (D.K., M.G.G., L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4764-612X","authenticated-orcid":true,"given":"Elizabeth G.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2696-2852","authenticated-orcid":true,"given":"Rashedeh","family":"Roshani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-6053","authenticated-orcid":true,"given":"Joshua M.","family":"Landman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2182","authenticated-orcid":true,"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-6145","authenticated-orcid":true,"given":"Kristin L.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2349-8214","authenticated-orcid":true,"given":"Mohammad Yaser","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanraj","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-9950","authenticated-orcid":true,"given":"Victoria L.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-0652","authenticated-orcid":true,"given":"Sonja I.","family":"Berndt","sequence":"additional","affiliation":[{"name":"US Dept of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD (S.I.B., J.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-6656","authenticated-orcid":true,"given":"Joshua 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(A.D.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-2586","authenticated-orcid":true,"given":"Faraz","family":"Bishehsari","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Center, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine (F.B.)."},{"name":"MD Anderson Cancer Center-UTHealth Houston Graduate School of Biomedical Sciences, Univ of Texas Houston (F.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-304X","authenticated-orcid":true,"given":"Miryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., 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E.","family":"Below","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."},{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-0366","authenticated-orcid":true,"given":"Kari E.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.)."},{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., 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Prevalence of overweight, obesity, and severe obesity among adults aged 20 and over: United States, 1960\u20131962 through 2017\u20132018. NCHS Health E-Stats; 2020."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2021.20410"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00414-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2022.100099"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00346-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0129"},{"key":"e_1_3_3_9_2","first-page":"A53","article-title":"Socioeconomic status and prevalence of obesity and diabetes in a Mexican American community, Cameron County, Texas, 2004-2007.","volume":"7","author":"Fisher-Hoch SP","year":"2010","unstructured":"Fisher-Hoch SP, Rentfro AR, Salinas JJ, Perez A, Brown HS, Reininger BM, Restrepo BI, Wilson JG, Hossain MM, Rahbar MH, et al. 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