{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:03:25Z","timestamp":1785593005887,"version":"3.56.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiac involvement is the main determinant of adverse outcomes in Fabry disease. The study aimed to investigate cardiovascular outcomes in patients with Fabry disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a multicenter, retrospective, longitudinal study of consecutively referred adult patients with Fabry disease. The primary end point was the occurrence of major adverse cardiovascular events defined as a composite of cardiovascular death, major arrhythmic events, bradyarrhythmias requiring pacemaker implantation, and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 680 patients (age, 42.3\u00b115.9 years; 41.0% male; 68.7% on disease-specific therapy) were included. During a median follow-up of 7.1 (interquartile range, 3.9\u201311.6) years, 92 patients (13.5%) experienced a major adverse cardiovascular event. At 10 years, freedom from major adverse cardiovascular event was 85.1% (95% CI, 81.3\u201388.2) and was lower in men compared with women (76.1% [95% CI, 68.9\u201381.9] versus 91.3% [95% CI, 87.0\u201394.2]; log-rank \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      =26.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). On multivariable analysis, age (hazard ratio, 1.04 [95% CI, 1.01\u20131.06] per 1 year;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), estimated glomerular filtration rate (hazard ratio, 0.99 [95% CI, 0.98\u20130.99] per 1 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), QRS interval (hazard ratio, 1.02 [95% CI, 1.01\u20131.03] per 1 ms;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002), and left ventricular mass index (hazard ratio, 1.01 [95% CI, 1.00\u20131.01] per 1 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.032) were independent predictors of major adverse cardiovascular events during follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This study shows that the prevention and treatment of cardiovascular disease remain an unmet need for patients with Fabry disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.125.005361","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:00:13Z","timestamp":1770372013000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiovascular Morbidity and Mortality in Fabry Disease"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-988X","authenticated-orcid":true,"given":"Emanuele","family":"Monda","sequence":"first","affiliation":[{"name":"Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Monaldi Hospital, Naples, Italy (E. 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Lillo, M.C.M., F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-0555","authenticated-orcid":true,"given":"Maria Chiara","family":"Meucci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (R. Lillo, M.C.M., F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-6268","authenticated-orcid":true,"given":"Letizia","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery (L.S., G.I.), Federico II University, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Parisi","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence &amp; Complex Diseases of the Heart-ERN GUARD-Heart, Florence, Italy (E. 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