{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:53:28Z","timestamp":1790934808036,"version":"4.1.0"},"reference-count":130,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Hypertension is a leading risk factor for cardiovascular disease, with lifestyle interventions, particularly diet, playing a pivotal role in its management. Recent advancements in personalized nutrition that tailor dietary recommendations based on an individual\u2019s unique biology (eg, genetics, microbiome) and lifestyle factors can potentially improve blood pressure control. Indeed, emerging evidence suggests that personalized nutrition can result in more effective and sustained blood pressure reductions than general dietary guidelines. This review explores the current evidence supporting personalized nutrition as a novel strategy for managing hypertension, while leveraging established approaches for controlling glycemia. We evaluate studies integrating genetic markers and genomics, gut microbiome profiles, and metabolic phenotypes to design personalized dietary interventions to reduce blood pressure. Specifically, we discuss how nutritional factors, including sodium and fiber intake and diets such as the Dietary Approaches to Stop Hypertension, interact with an individual\u2019s genetic predisposition and gut microbiota composition to influence blood pressure outcomes. However, challenges remain in translation to clinical practice, including the need for larger, long-term trials in real-world settings, accessibility of advanced dietary assessments, considerations of patient adherence, and equity. We highlight the potential of personalized nutrition to refine hypertension treatment and call for further research to optimize its implementation at the public health and clinical practice levels. Particularly in low- and middle-income countries, where hypertension prevalence is higher, cost is an important consideration for successful implementation. However, some personalized treatments focusing on diet are cost-effective and should be prioritized. Ultimately, a personalized nutrition approach may offer a powerful tool for mitigating the global burden of hypertension through targeted, individualized dietary strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.125.005566","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:00:42Z","timestamp":1790931642000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Nutrition for Hypertension: Current Evidence and Future Directions"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5088-5072","authenticated-orcid":true,"given":"Phoebe","family":"Cheong","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University (P.C., C.M., F.Z.M., M.S.)."},{"name":"Victorian Heart Institute, Monash University, Clayton, Australia (P.C., C.M., F.Z.M., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2310-2187","authenticated-orcid":true,"given":"Cass","family":"Mangan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University (P.C., C.M., F.Z.M., M.S.)."},{"name":"Victorian Heart Institute, Monash University, Clayton, Australia (P.C., C.M., F.Z.M., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-5990","authenticated-orcid":true,"given":"Erin D.","family":"Clarke","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing (E.D.C., J.S., C.E.C.), University of Newcastle, Callaghan, Australia."},{"name":"Food &amp; Nutrition Research Program (E.D.C., J.S., C.E.C.), Hunter Medical Research Institute, New Lambton Heights, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-8960","authenticated-orcid":true,"given":"Jordan","family":"Stanford","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing (E.D.C., J.S., C.E.C.), University of Newcastle, Callaghan, Australia."},{"name":"Food &amp; Nutrition Research Program (E.D.C., J.S., C.E.C.), Hunter Medical Research Institute, New Lambton Heights, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-2538","authenticated-orcid":true,"given":"Murray J.","family":"Cairns","sequence":"additional","affiliation":[{"name":"School of Biomedical Science &amp; Pharmacy (M.J.C.), University of Newcastle, Callaghan, Australia."},{"name":"Precision Medicine Research Program (M.J.C.), Hunter Medical Research Institute, New Lambton Heights, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-756X","authenticated-orcid":true,"given":"Clare E.","family":"Collins","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing (E.D.C., J.S., C.E.C.), University of Newcastle, Callaghan, Australia."},{"name":"Food &amp; Nutrition Research Program (E.D.C., J.S., C.E.C.), Hunter Medical Research Institute, New Lambton Heights, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-9991","authenticated-orcid":true,"given":"Francine Z.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University (P.C., C.M., F.Z.M., M.S.)."},{"name":"Victorian Heart Institute, Monash University, Clayton, Australia (P.C., C.M., F.Z.M., M.S.)."},{"name":"Baker Heart and Diabetes Institute, Melbourne, Australia (F.Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-9550","authenticated-orcid":true,"given":"Matthew","family":"Snelson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University (P.C., C.M., F.Z.M., M.S.)."},{"name":"Victorian Heart Institute, Monash University, Clayton, Australia (P.C., C.M., F.Z.M., M.S.)."},{"name":"Nutrition &amp; Health Innovation Research Institute, Edith Cowan University, Perth, Australia (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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