{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:53:33Z","timestamp":1790934813514,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Genomic and Precision Medicine"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Pathogenic and likely pathogenic variants in filamin C (\n                      <jats:italic toggle=\"yes\">FLNC<\/jats:italic>\n                      ) cause a broad spectrum of cardiomyopathies. However, available genotype-phenotype data are derived predominantly from European and North American populations, with limited representation of admixed populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We characterized carriers of pathogenic\/likely pathogenic\n                      <jats:italic toggle=\"yes\">FLNC<\/jats:italic>\n                      variants identified among 2654 unrelated probands undergoing exome sequencing for suspected inherited cardiomyopathy and their relatives identified through cascade screening. Clinical, electrocardiographic, imaging, genetic, and longitudinal data were analyzed according to cardiomyopathy phenotype and variant class. Genetic ancestry was evaluated. Associations with arrhythmic, heart failure, and composite outcomes were examined in exploratory analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The cohort included 97 carriers (58 probands, 39 relatives), of whom 72 had cardiomyopathy and 25 were phenotype-negative at evaluation. Truncating variants predominated among patients with arrhythmogenic cardiomyopathy and dilated cardiomyopathy, whereas missense variants were concentrated among those with hypertrophic cardiomyopathy and restrictive cardiomyopathy. Arrhythmogenic cardiomyopathy and dilated cardiomyopathy were characterized by a greater burden of ventricular arrhythmias, low QRS voltage, systolic dysfunction, and myocardial fibrosis, whereas hypertrophic cardiomyopathy and restrictive cardiomyopathy showed greater wall thickness and more atrial arrhythmias. Twelve pathogenic\/likely pathogenic variants absent from gnomAD and ClinVar were identified. Ancestry analysis confirmed heterogeneous genetic backgrounds but detected no ancestry-related differences in variant class or phenotype. In exploratory outcome analyses, nonsustained ventricular tachycardia, low QRS voltage, and late gadolinium enhancement were associated with outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      This deeply phenotyped Brazilian cohort expands the\n                      <jats:italic toggle=\"yes\">FLNC<\/jats:italic>\n                      variant spectrum and supports broad genotype-phenotype associations across an admixed population. Exploratory findings suggest that markers of ventricular arrhythmia and myocardial fibrosis may complement left ventricular ejection fraction in future risk-stratification strategies, although validation in larger, independent cohorts is required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circgen.126.005733","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:01:42Z","timestamp":1790931702000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["<i>FLNC<\/i>\n                    -Related Cardiomyopathies in an Admixed Population: Expanding the Genotype-Phenotype Spectrum and Clinical Correlates"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-8982","authenticated-orcid":true,"given":"Natalia Quintella Sangiorgi","family":"Olivetti","sequence":"first","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."},{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil (N.Q.S.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Sacilotto","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia de Barros Negri","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-0940","authenticated-orcid":true,"given":"Silas","family":"Furquim","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rya","family":"Pagotti","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Moreira","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4764-657X","authenticated-orcid":true,"given":"Paula de Mendon\u00e7a","family":"Senra","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6036-5474","authenticated-orcid":true,"given":"Giovanna","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-2906","authenticated-orcid":true,"given":"Kelvin","family":"Vilalva","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-8040","authenticated-orcid":true,"given":"Fernanda","family":"Andrade","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-8031","authenticated-orcid":true,"given":"Mariana Lombardi Peres de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5146-9645","authenticated-orcid":true,"given":"Emanuelle Leon\u00edlia","family":"Marques","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-3506","authenticated-orcid":true,"given":"Jose Salvatore Leister","family":"Patane","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-976X","authenticated-orcid":true,"given":"Lucas Vieira Lacerda","family":"Pires","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-4138","authenticated-orcid":true,"given":"Angelica Nakagawa","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-5540","authenticated-orcid":true,"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-5958","authenticated-orcid":true,"given":"Francisco da Costa","family":"Darrieux","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-2275","authenticated-orcid":true,"given":"Mauricio","family":"Scanavacca","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8805","authenticated-orcid":true,"given":"F\u00e1bio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-1792","authenticated-orcid":true,"given":"Jose E.","family":"Krieger","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazilian Genomic Cardiovascular Consortium, MAPA Genoma, Brazil (N.Q.S.O., L.S., J.d.B.N.F., S.F., M.P., B.M.S., M.M., P.M.S., G.N., K.V., F.A., M.L.P.d.C., E.L.M., J.S.L.P., L.V.L.P., A.N.L., A.C.P., F.d.C.D., M.S., F.F., J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.05.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.927"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.12.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053521"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1054-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.36660\/abchf.20240059i"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21922"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.08.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001584"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.09.029"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63169"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.03.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl3564"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00610-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1061"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.01.022"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.06.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318157"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.072"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.5543"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.806"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1110s43"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1974"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.24072\/pcjournal.503"}],"container-title":["Circulation: Genomic and Precision Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCGEN.126.005733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:01:42Z","timestamp":1790931702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGEN.126.005733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":28,"alternative-id":["10.1161\/CIRCGEN.126.005733"],"URL":"https:\/\/doi.org\/10.1161\/circgen.126.005733","relation":{},"ISSN":["2574-8300"],"issn-type":[{"value":"2574-8300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005733"}}