{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:55:26Z","timestamp":1790034926963,"version":"4.0.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Cardiovasc Genet"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>It is not known whether the genes involved with endurance performance during young adulthood are also involved with changes in performance. We examined the associations of gene variants with symptom-limited exercise test duration at baseline and decrease in duration over 20 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 3783 (1835 black, 1948 white) and 2335 (1035 black, 1300 white) participants from the Coronary Artery Risk Development in Young Adults study were included in the baseline and 20-year models, respectively. Two hundred seventeen single-nucleotide polymorphisms (SNPs) in black participants and 171 in white participants from 17 genes were genotyped. In blacks, 5 SNPs in the\n              <jats:italic>ATP1A2<\/jats:italic>\n              ,\n              <jats:italic>HIF1A<\/jats:italic>\n              ,\n              <jats:italic>NOS3<\/jats:italic>\n              , and\n              <jats:italic>PPARGC1A<\/jats:italic>\n              loci tended to be associated (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) with baseline duration in a multivariate regression model. Blacks (n=99) with at least 4 of the most-favorable genotypes at these loci had an \u22482-minute longer baseline duration than those with only 2 such genotypes (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). In whites, the\n              <jats:italic>HIF1A<\/jats:italic>\n              rs1957757 and\n              <jats:italic>PPARGC1A<\/jats:italic>\n              rs3774909 markers tended to be associated with baseline duration, but the association of a multimarker construct of the most-favorable genotypes at both SNPs with baseline duration was not statistically significant. In whites, 4 SNPs in the\n              <jats:italic>AGT<\/jats:italic>\n              ,\n              <jats:italic>AMPD1<\/jats:italic>\n              ,\n              <jats:italic>ANG<\/jats:italic>\n              , and\n              <jats:italic>PPARGC1A<\/jats:italic>\n              loci tended to be associated with decrease in exercise duration over 20 years, and those with all 4 favorable genotypes (n=40) had a 0.8-minute less decline in duration compared with those with none or 1 (n=232) (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              In multimarker constructs, alleles at genes related to skeletal muscle Na\n              <jats:sup>+<\/jats:sup>\n              \/K\n              <jats:sup>+<\/jats:sup>\n              transport, hypoxia, and mitochondrial metabolism are associated with symptom-limited exercise test duration over time in adults.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgenetics.110.957183","type":"journal-article","created":{"date-parts":[[2010,10,16]],"date-time":"2010-10-16T03:04:50Z","timestamp":1287198290000},"page":"531-538","source":"Crossref","is-referenced-by-count":12,"title":["Association of Single-Nucleotide Polymorphisms From 17 Candidate Genes With Baseline Symptom-Limited Exercise Test Duration and Decrease in Duration Over 20 Years"],"prefix":"10.1161","volume":"3","author":[{"given":"Mark A.","family":"Sarzynski","sequence":"first","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomo","family":"Rankinen","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sternfeld","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Grove","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bouchard","sequence":"additional","affiliation":[{"name":"From the Human Genomics Laboratory (M.A.S., T.R., C.B.), Pennington Biomedical Research Center, Baton Rouge, La; Division of Research (B.S., S.S.), Kaiser Permanente Medical Care Program, Oakland, Calif; Human Genetics Center (M.L.G.) and Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center; Houston, Tex; and School of Public Health (D.R.J.), University of Minnesota, Minneapolis, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430170057028"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.23.3092"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520380029031"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(98)00030-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199802000-00013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.1.357"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000153540"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181844179"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1971"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199202000-00004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02168"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1669"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.2.182"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/383251"},{"key":"e_1_3_3_18_2","unstructured":"Gauderman WJ Morrison JM. 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