{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:41:05Z","timestamp":1772271665511,"version":"3.50.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Cardiovasc Genet"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Obstructive coronary artery disease diagnosis in symptomatic patients often involves noninvasive testing before invasive coronary angiography. A blood-based gene expression score (GES) was previously validated in nondiabetic patients referred for invasive coronary angiography but not in symptomatic patients referred for myocardial perfusion imaging (MPI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This prospective, multicenter study obtained peripheral blood samples for GES before MPI in 537 consecutive patients. Patients with abnormal MPI usually underwent invasive coronary angiography; all others had research coronary computed tomographic angiography, with core laboratories defining coronary anatomy. A total of 431 patients completed GES, coronary imaging (invasive coronary angiography or computed tomographic angiography), and MPI. Mean age was 56\u00b110 years (48% women). The prespecified primary end point was GES receiver-operating characteristics analysis to discriminate \u226550% stenosis (15% prevalence by core laboratory analysis). Area under the receiver-operating characteristics curve for GES was 0.79 (95% confidence interval, 0.73\u20130.84;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), with sensitivity, specificity, and negative predictive value of 89%, 52%, and 96%, respectively, at a prespecified threshold of \u226415 with 46% of patients below this score. The GES outperformed clinical factors by receiver-operating characteristics and reclassification analysis and showed significant correlation with maximum percent stenosis. Six-month follow-up on 97% of patients showed that 27 of 28 patients with adverse cardiovascular events or revascularization had GES &gt;15. Site and core-laboratory MPI had areas under the curve of 0.59 and 0.63, respectively, significantly less than GES.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>GES has high sensitivity and negative predictive value for obstructive coronary artery disease. In this population clinically referred for MPI, the GES outperformed clinical factors and MPI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01117506.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgenetics.112.964015","type":"journal-article","created":{"date-parts":[[2013,2,16]],"date-time":"2013-02-16T07:49:51Z","timestamp":1361000991000},"page":"154-162","source":"Crossref","is-referenced-by-count":66,"title":["A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion Imaging The COMPASS Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Gregory S.","family":"Thomas","sequence":"first","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szilard","family":"Voros","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"McPherson","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Winn","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Bateman","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Elashoff","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao D.","family":"Lieu","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); Stony Brook University Medical Center, Stony Brook, NY (S.V.); Vanderbilt University, Nashville, TN (J.A.M.); Yale University School of Medicine, New Haven, CN (A.J.L.); Scripps Translational Science Institute, La Jolla, CA (M.E.W.); University of Missouri, Kansas City (T.M.B.); CardioDx, Inc, Palo Alto, CA (M.R.E., H.D.L., A.M.J., S.E.D., S.R.); New York University School of Medicine, New..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Long Beach Memorial Medical Center, Long Beach, CA, and University of California, Irvine (G.S.T.); 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