{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:46:32Z","timestamp":1778755592474,"version":"3.51.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ Cardiovasc Genet"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Long-QT syndrome (LQTS) is characterized by such striking clinical heterogeneity that, even among family members carrying the same mutation, clinical outcome can range between sudden death and no symptoms. We investigated the role of genetic variants as modifiers of risk for cardiac events in patients with LQTS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In a matched case\u2013control study including 112 patient duos with LQTS from France, Italy, and Japan, 25 polymorphisms were genotyped based on either their association with QTc duration in healthy populations or on their role in adrenergic responses. The duos were composed of 2 relatives harboring the same heterozygous\n              <jats:italic>KCNQ1<\/jats:italic>\n              or\n              <jats:italic>KCNH2<\/jats:italic>\n              mutation: 1 with cardiac events and 1 asymptomatic and untreated. The findings were then validated in 2 independent founder populations totaling 174 symptomatic and 162 asymptomatic patients with LQTS, and a meta-analysis was performed. The\n              <jats:italic>KCNQ1<\/jats:italic>\n              rs2074238 T-allele was significantly associated with a decreased risk of symptoms 0.34 (0.19\u20130.61;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0002) and with shorter QTc (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) in the combined discovery and replication cohorts.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              We provide evidence that the\n              <jats:italic>KCNQ1<\/jats:italic>\n              rs2074238 polymorphism is an independent risk modifier with the minor T-allele conferring protection against cardiac events in patients with LQTS. This finding is a step toward a novel approach for risk stratification in patients with LQTS.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgenetics.113.000023","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T04:54:29Z","timestamp":1373950469000},"page":"354-361","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Identification of a\n            <i>KCNQ1<\/i>\n            Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome"],"prefix":"10.1161","volume":"6","author":[{"given":"Sabine","family":"Duchatelet","sequence":"first","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Peat","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Denjoy","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Itoh","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Berthet","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Ohno","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Fressart","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Monti","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Crocamo","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Pedrazzini","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Dagradi","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vicentini","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Klug","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Brink","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Althea","family":"Goosen","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Swan","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauri","family":"Toivonen","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annukka M.","family":"Lahtinen","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimmo","family":"Kontula","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Alfred L.","family":"George","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David-Alexandre","family":"Tr\u00e9gou\u00ebt","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Guicheney","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From INSERM, UMR S956, Paris, France (S.D., R.A.P., I.D., M.B., P.G.); Universit\u00e9 Paris 06, Pierre et Marie Curie, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (S.D., R.A.P., M.B., D.-A.T., P.G.); Department of Molecular Medicine (L.C., F.D., A.V., P.J.S.), Division of Biostatistics and Clinical Epidemiology, Department of Public Health, Neurological Sciences, Experimental and Forensic Medicine (M.C.M., C.C.), University of Pavia, Pavia, Italy; Department of Cardiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.962019"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271204"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.529"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.12.035"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.069"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.005"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.06.050"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.879643"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022147"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1136"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.11.009"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1790"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.364"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.362"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201866"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201489"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.89"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.07.023"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.572453"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/17431380410032689"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.782"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.772533"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.08.036"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1753-6561-1-s1-s156"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960191209"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(94)80052-9"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/513895"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym159"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.959049"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.511"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2778"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.726950"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.03.049"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.065"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr473"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn564"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.136127.111"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.137323.112"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-11"}],"container-title":["Circulation: Cardiovascular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCGENETICS.113.000023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:49:10Z","timestamp":1715564950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGENETICS.113.000023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1161\/CIRCGENETICS.113.000023"],"URL":"https:\/\/doi.org\/10.1161\/circgenetics.113.000023","relation":{},"ISSN":["1942-325X","1942-3268"],"issn-type":[{"value":"1942-325X","type":"print"},{"value":"1942-3268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}