{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:57:21Z","timestamp":1754261841253},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ Cardiovasc Genet"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              Adrenomedullin (ADM) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function. Single nucleotide polymorphisms of the\n              <jats:italic>ADM<\/jats:italic>\n              gene are associated with blood pressure variability, and elevated levels of plasma midregional proadrenomedullin (MR-pro-ADM) are associated with cardiovascular diseases.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We investigated the sources of variability of\n              <jats:italic>ADM<\/jats:italic>\n              gene expression and plasma MR-pro-ADM concentrations in the general population, and their relationship with markers of atherosclerosis. MR-pro-ADM levels were assessed in 4155 individuals who underwent evaluation of carotid intima-media thickness and arterial rigidity (reflection index and stiffness index). In a subsample of 1372 individuals,\n              <jats:italic>ADM<\/jats:italic>\n              gene expression was assessed as part of a transcriptomic study of circulating monocytes. Nongenetic factors explained 45.8% and 7.5% of MR-pro-ADM and\n              <jats:italic>ADM<\/jats:italic>\n              expression variability, respectively.\n              <jats:italic>ADM<\/jats:italic>\n              expression correlated with plasma C-reactive protein, interleukin-receptor 1A, and myeloperoxidase, whereas MR-pro-ADM levels correlated with C-terminal proendothelin-1, creatinine, and N-terminal pro\u2013B-type natriuretic peptide. Genome-wide association study of\n              <jats:italic>ADM<\/jats:italic>\n              expression and MR-pro-ADM levels both identified a single locus encompassing the\n              <jats:italic>ADM<\/jats:italic>\n              gene.\n              <jats:italic>ADM<\/jats:italic>\n              expression was associated with 1 single nucleotide polymorphism rs11042717 (\n              <jats:italic>P<\/jats:italic>\n              =2.36\u00d710\n              <jats:sup>\u221212<\/jats:sup>\n              ), whereas MR-pro-ADM was associated with 2 single nucleotide polymorphisms with additive effects, rs2957692 (\n              <jats:italic>P<\/jats:italic>\n              =1.54\u00d710\n              <jats:sup>\u221213<\/jats:sup>\n              ) and rs2957717 (\n              <jats:italic>P<\/jats:italic>\n              =4.24\u00d710\n              <jats:sup>\u22128<\/jats:sup>\n              ). Reflection index was independently associated with rs11042717 (\n              <jats:italic>P<\/jats:italic>\n              &lt;10\n              <jats:sup>\u20134<\/jats:sup>\n              ) and\n              <jats:italic>ADM<\/jats:italic>\n              expression (\n              <jats:italic>P<\/jats:italic>\n              =0.0002) but not with MR-pro-ADM. Weaker associations were observed for stiffness index. Intima-media thickness was not related to\n              <jats:italic>ADM<\/jats:italic>\n              single nucleotide polymorphisms or expression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              These results support an involvement of the\n              <jats:italic>ADM<\/jats:italic>\n              gene in the modulation of peripheral vascular tone.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circgenetics.113.000456","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:41:58Z","timestamp":1406101318000},"page":"634-641","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Adrenomedullin and Arterial Stiffness"],"prefix":"10.1161","volume":"7","author":[{"given":"Farzin","family":"Beygui","sequence":"first","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp S.","family":"Wild","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Germain","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaele","family":"Castagn\u00e9","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl J.","family":"Lackner","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germaine C.","family":"Verwoert","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirill V.","family":"Tarasov","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David-Alexandre","family":"Tr\u00e9gou\u00ebt","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Cambien","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Tiret","sequence":"additional","affiliation":[{"name":"From UMR_S 1166, Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00358-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000015462.11528.28"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051110"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302390"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.038"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq322"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302956"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.157842"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.06.019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.178095"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.193"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.887"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.112.191874"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.132"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.S129"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000213"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10405"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.922"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010693"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.03.006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.110.961557"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn564"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.959817"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.203117"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.33"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds098"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.652842"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.42"}],"container-title":["Circulation: Cardiovascular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCGENETICS.113.000456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:47:02Z","timestamp":1715564822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGENETICS.113.000456"}},"subtitle":["Integrative Approach Combining Monocyte\n            <i>ADM<\/i>\n            Expression, Plasma MR-Pro-ADM, and Genome-Wide Association Study"],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1161\/CIRCGENETICS.113.000456"],"URL":"https:\/\/doi.org\/10.1161\/circgenetics.113.000456","relation":{},"ISSN":["1942-325X","1942-3268"],"issn-type":[{"value":"1942-325X","type":"print"},{"value":"1942-3268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}