{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:58:12Z","timestamp":1768885092705,"version":"3.49.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Patients with congestive heart failure (CHF) often have low serum triiodothyronine (T\n            <jats:sub>3<\/jats:sub>\n            ) concentrations. In a rodent model of myocardial infarction-induced CHF and low serum T\n            <jats:sub>3<\/jats:sub>\n            , we hypothesized that replacing T\n            <jats:sub>3<\/jats:sub>\n            to euthyroid levels would improve left ventricular function without producing untoward signs of thyrotoxicosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Adult male Sprague-Dawley rats were subjected to left anterior descending coronary artery ligation (myocardial infarction). One week post-myocardial infarction, left ventricular fractional shortening was significantly reduced to 22\ufffd1% in CHF animals versus 38\ufffd1% for sham-operated controls (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Serum T\n            <jats:sub>3<\/jats:sub>\n            concentration was also significantly reduced (80\ufffd3 versus 103\ufffd6 ng\/dL;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), in CHF animals versus Shams. At 9 weeks post-myocardial infarction, systolic function (+dP\/dt max) was significantly attenuated in CHF animals (4773\ufffd259 versus 6310\ufffd267 mmHg\/s;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) as well as diastolic function measured by half time to relaxation (15.9\ufffd1.2 versus 11.1\ufffd0.3 ms;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). \u03b1-myosin heavy chain expression was also significantly reduced by 77% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), and \u03b2-myosin heavy chain expression was increased by 21%. Continuous T\n            <jats:sub>3<\/jats:sub>\n            replacement was initiated 1 week post-myocardial infarction with osmotic mini-pumps (6 \u03bcg\/kg\/d), which returned serum T\n            <jats:sub>3<\/jats:sub>\n            concentrations to levels similar to Sham controls while resting conscious heart rate, arterial blood pressure and the incidence of arrhythmias were not different. At 9 weeks, systolic function was significantly improved by T\n            <jats:sub>3<\/jats:sub>\n            replacement (6279\ufffd347 mmHg\/s;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) and a trend toward improved diastolic function (12.3\ufffd0.6 ms) was noted. T\n            <jats:sub>3<\/jats:sub>\n            replacement in CHF animals also significantly increased \u03b1- and reduced \u03b2-MHC expression, (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            These data indicate that T\n            <jats:sub>3<\/jats:sub>\n            replacement to euthyroid levels improves systolic function and tends to improve diastolic function, potentially through changes in myocardial gene expression.\n          <\/jats:p>","DOI":"10.1161\/circheartfailure.108.810747","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T01:06:38Z","timestamp":1238029598000},"page":"243-252","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Physiological Replacement of T\n            <sub>3<\/sub>\n            Improves Left Ventricular Function in an Animal Model of Myocardial Infarction-Induced Congestive Heart Failure"],"prefix":"10.1161","volume":"2","author":[{"given":"Kyle K.","family":"Henderson","sequence":"first","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Danzi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer T.","family":"Paul","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Leya","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen M.","family":"Samarel","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and the Cardiovascular Institute (K.K.H., J.T.P., G.L., A.M.S.), Loyola University Medical Center, Maywood, Ill; and Department of Medicine and the Feinstein Institute for Medical Research (S.D., I.K.), North Shore University Hospital, Manhasset, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311306"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.678326"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(83)90004-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-4-4-378"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68584-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7182"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-652"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1229"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.59.2.3742743"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)82162-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.89.7.591"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00160-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.2.8033338"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.5.E951"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90462-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00950-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0291"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2210"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90402-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.6.E1319"},{"key":"e_1_3_2_21_2","first-page":"H801","volume":"255","year":"1988","unstructured":"Gay RG, Graham S, Aguirre M, Goldman S, Morkin E. 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