{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:44:57Z","timestamp":1791146697104,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            In patients with chronic heart failure (CHF), the presence of sleep-disordered breathing, including either obstructive sleep apnea or Cheyne-Stokes respiration-central sleep apnea, is associated with a poor prognosis. A large-scale clinical trial showed that continuous positive airway pressure (CPAP) did not improve the prognosis of such patients with CHF, probably because of insufficient sleep-disordered breathing suppression. Recently, it was reported that adaptive servo-ventilation (ASV) can effectively treat sleep-disordered breathing. However, there are no specific data about the efficacy of flow-triggered ASV for cardiac function in patients with CHF with sleep-disordered breathing. The aim of this study was to compare the efficacy of flow-triggered ASV to CPAP in patients with CHF with coexisting obstructive sleep apnea and Cheyne-Stokes respiration-central sleep apnea.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Thirty-one patients with CHF, defined as left ventricular ejection fraction &lt;50% and New York Heart Association class \u2265II, with coexisting obstructive sleep apnea and Cheyne-Stokes respiration-central sleep apnea, were randomly assigned to either CPAP or flow-triggered ASV. The suppression of respiratory events, changes in cardiac function, and compliance with the devices during the 3-month study period were compared. Although both devices decreased respiratory events, ASV more effectively suppressed respiratory events (\u0394AHI [apnea-hypopnea index], \u221235.4\u00b119.5 with ASV; \u221223.2\u00b112.0 with CPAP,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Compliance was significantly greater with ASV than with CPAP (5.2\u00b10.9 versus 4.4\u00b11.1 h\/night,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). The improvements in quality-of-life and left ventricular ejection fraction were greater in the ASV group (\u0394LVEF [left ventricular ejection fraction], +9.1\u00b14.7% versus +1.9\u00b110.9%).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            These results suggest that patients with coexisting obstructive sleep apnea and Cheyne-Stokes respiration-central sleep apnea may receive greater benefit from treatment with ASV than with CPAP.\n          <\/jats:p>","DOI":"10.1161\/circheartfailure.109.868786","type":"journal-article","created":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T03:15:15Z","timestamp":1258773315000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["Effect of Flow-Triggered Adaptive Servo-Ventilation Compared With Continuous Positive Airway Pressure in Patients With Chronic Heart Failure With Coexisting Obstructive Sleep Apnea and Cheyne-Stokes Respiration"],"prefix":"10.1161","volume":"3","author":[{"given":"Takatoshi","family":"Kasai","sequence":"first","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Usui","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotake","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Takata","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Narui","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamashina","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. Yamaguchi), Toranomon Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ich","family":"Momomura","sequence":"additional","affiliation":[{"name":"From the Sleep Center (T.K., K.N.), Toranomon Hospital; Department of Cardiology (Y.U., Y.T., A.Y.), Tokyo Medical University, Tokyo, Japan; Cardiovascular Division (T. Yoshioka, S.-I.M.), Saitama Medical Center, Jichi Medical University, Saitama, Japan; Department of Cardiology (N.Y.), Juntendo University, School of Medicine; and Cardiovascular Center (T. 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