{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:08:22Z","timestamp":1785434902206,"version":"3.56.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The relations between chronic kidney disease (CKD) and incident heart failure remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We related CKD to incident nonfatal heart failure and cardiovascular (CVD) death (as separate and combined end points) in 10 181 male participants (mean age, 67 years). Kidney function was assessed by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation in clinically relevant categories of &lt;60 and \u226560 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              (referent) and &lt;45, 45 to 60, 60 to 90, and \u226590 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              (referent). During follow-up (mean, 10.1 years; range, 0.03 to 12.2), 439 developed heart failure and 832 had CVD death\/heart failure. In multivariable models, men with eGFR &lt;60 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              had a 2-fold risk of heart failure (95% confidence interval, 1.62 to 2.56,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) compared with referent category. The hazard ratio (with corresponding 95% confidence interval) for development of heart failure according to eGFR categories of 60 to 90, 45 to 60, and &lt;45 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              compared with referent category were 1.24 (0.98 to 1.56), 2.58 (1.91 to 3.49), and 1.52 (0.92 to 2.76), respectively. In the analyses restricted to subgroup of nondiabetic individuals and normotensive individuals at baseline (n=7545), men with eGFR &lt;60 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              had a 2.2-fold risk of heart failure (95% confidence interval, 1.66 to 2.95), compared with men with eGFR \u226560 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              . Additionally, risk of heart failure or CVD death was &gt;2.5-fold higher among individuals with eGFR 45 to 60 and &lt;45 mL \u00b7 min\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7 1.73 m\n              <jats:sup>\u22122<\/jats:sup>\n              , compared with referent category.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Moderate level of CKD, even in absence of diabetes and hypertension at baseline, is associated with a higher risk of development of heart failure and CVD death\/heart failure in men.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.109.899070","type":"journal-article","created":{"date-parts":[[2011,1,8]],"date-time":"2011-01-08T02:10:36Z","timestamp":1294452636000},"page":"138-144","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Chronic Kidney Disease and the Risk of Heart Failure in Men"],"prefix":"10.1161","volume":"4","author":[{"given":"Ravi","family":"Dhingra","sequence":"first","affiliation":[{"name":"From the Section of Cardiology (R.D.), Dartmouth Hitchcock Medical Center, Lebanon, NH; the Division of Aging (R.D., J.M.G., L.D.) and Preventive Medicine (J.M.G.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and the Massachusetts Veterans Epidemiology Research and Information Center and Geriatric Research, Education, and Clinical Center (J.M.G., L.D.), VA Boston Healthcare System, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology (R.D.), Dartmouth Hitchcock Medical Center, Lebanon, NH; the Division of Aging (R.D., J.M.G., L.D.) and Preventive Medicine (J.M.G.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and the Massachusetts Veterans Epidemiology Research and Information Center and Geriatric Research, Education, and Clinical Center (J.M.G., L.D.), VA Boston Healthcare System, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Djouss\u00e9","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology (R.D.), Dartmouth Hitchcock Medical Center, Lebanon, NH; the Division of Aging (R.D., J.M.G., L.D.) and Preventive Medicine (J.M.G.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and the Massachusetts Veterans Epidemiology Research and Information Center and Geriatric Research, Education, and Clinical Center (J.M.G., L.D.), VA Boston Healthcare System, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095676.90936.80"},{"key":"e_1_3_3_3_2","unstructured":"Kannel WB Wolf PA Garrison RJ eds. 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