{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:06:40Z","timestamp":1791410800733,"version":"4.3.3"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Although much is known about the risk factors for poor outcome in patients hospitalized with acute heart failure and left ventricular dysfunction, much less is known about the syndrome of acute heart failure primarily affecting the right ventricle (acute right heart failure).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              By using Stanford Hospital's pulmonary hypertension database, we identified consecutive acute right heart failure hospitalizations in patients with PAH. We used longitudinal regression analysis with the generalized estimating equations method to identify factors associated with an increased likelihood of 90-day mortality or urgent transplantation. From June 1999 to September 2009, 119 patients with PAH were hospitalized for acute right heart failure (207 episodes). Death or urgent transplantation occurred in 34 patients by 90 days of admission. Multivariable analysis identified a higher respiratory rate on admission (&gt;20 breaths per minute; OR, 3.4; 95% CI, 1.5\u20137.8), renal dysfunction on admission (glomerular filtration rate &lt;45 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              ; OR, 2.7; 95% CI, 1.2\u20136.3), hyponatremia (serum sodium \u2264136 mEq\/L; OR, 3.6; 95% CI, 1.7\u20137.9), and tricuspid regurgitation severity (OR, 2.5 per grade; 95% CI, 1.2\u20135.5) as independent factors associated with an increased likelihood of death or urgent transplantation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>These results highlight the high mortality after hospitalizations for acute right heart failure in patients with PAH. Factors identifiable within hours of hospitalization may help predict the likelihood of death or the need for urgent transplantation in patients with PAH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.110.949933","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T05:29:51Z","timestamp":1315632591000},"page":"692-699","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":119,"title":["Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"4","author":[{"given":"Fran\u00e7ois","family":"Haddad","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Peterson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fuh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina T.","family":"Kudelko","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicio","family":"de Jesus Perez","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Skhiri","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Vagelos","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingela","family":"Schnittger","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Y.","family":"Denault","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; and Department of Anesthesia, Montreal University, Montreal, Quebec, Canada (A.Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona L.","family":"Doyle","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine (F.H., M.S., R.V., I.S.), Department of Medicine (T.P., E.F.), Division of Pulmonary and Critical Care Medicine (K.T.K., V.d.J.P., R.L.D., R.T.Z.), and Division of Cardiology, Department of Pediatrics (D.N.R.), Stanford University, Stanford, CA; 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