{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:19:48Z","timestamp":1792441188952,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Cardiac transplantation, a procedure nearly abandoned in the 1970s, has evolved into the standard of care for appropriate patients with end-stage heart failure. Much of this success has been due to improvements in immunosuppression, including the introduction of a triple-drug regimen. Retrospective reports suggested that single-drug immunosuppression with tacrolimus was feasible. As such, a prospective, randomized trial was conducted to test this approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              One hundred fifty adult de novo heart transplant recipients were enrolled in a prospective, randomized, controlled, open-label trial comparing tacrolimus monotherapy (MONO) with tacrolimus and mycophenolate mofetil therapy (COMBO). Corticosteroids were used in the early postoperative period but discontinued in all patients over 8 to 9 weeks. The primary end point was the composite biopsy score at 6 months after transplant. Patients were followed for 1 to 5 years. The composite biopsy score was similar between groups at 6 and 12 months: 6-month MONO, 0.70\u00b10.44 (95% confidence interval, 0.60 to 0.80) versus COMBO, 0.65\u00b10.40 (95% confidence interval, 0.55 to 0.74;\n              <jats:italic>P<\/jats:italic>\n              =0.44). Allograft vasculopathy was assessed by angiography and intravascular ultrasound, with no significant differences noted. Three-year survival was also similar (92.4% MONO versus 97% COMBO;\n              <jats:italic>P<\/jats:italic>\n              =0.58, log-rank).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Addition of mycophenolate to single-agent immunosuppression did not provide an advantage over single-agent immunosuppression in terms of rejection, allograft vasculopathy, or 3-year survival. Corticosteroids, which have traditionally been a mainstay of therapy, were successfully discontinued in all patients. These conclusions are tempered by the limited statistical power associated with a sample size of only 150 patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00299221.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.110.958520","type":"journal-article","created":{"date-parts":[[2011,1,8]],"date-time":"2011-01-08T02:10:36Z","timestamp":1294452636000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["A Prospective, Randomized Trial of Single-Drug Versus Dual-Drug Immunosuppression in Heart Transplantation"],"prefix":"10.1161","volume":"4","author":[{"given":"David A.","family":"Baran","sequence":"first","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Zucker","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H.","family":"Arroyo","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Camacho","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Prevost-Fernandez","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Carr","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Adams","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Pardi","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Hou","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Binetti","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine","family":"McCahill","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Chichetti","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Viloria","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Gladys","family":"SanAgustin","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ebuenga-Smith","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Mele","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Martin","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Blicharz","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Wolski","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmilla","family":"Olesnicky","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Qian","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Gass","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Cohen","sequence":"additional","affiliation":[{"name":"From Newark Beth Israel Medical Center (D.A.B., M.J.Z., L.H.A., M.C., M.E.G., J.P.-F., C.C., L.A., S.P., V.H., M.B., J.M., J.C., V.V., M.G.S., J.E.-S., A.M., D.B., L.O., F.Q., M.C.), Newark, NJ; The Cleveland Clinic (S.J.N., K.W.), Cleveland, OH; and Westchester Medical Center (A.L.G.), Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"441","article-title":"Heart transplants: blessing or boondoggle?","volume":"3","author":"Lawrence SV","year":"1980","unstructured":"Lawrence SV. Heart transplants: blessing or boondoggle? Forum Med. 1980;3:441\u2013445.","journal-title":"Forum Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005083021912"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198209000-00011"},{"key":"e_1_3_3_5_2","first-page":"3054","article-title":"The clinical trial of fk 506 as primary and rescue immunosuppression in adult cardiac transplantation","volume":"23","author":"Armitage JM","year":"1991","unstructured":"Armitage JM, Kormos RL, Fung J, Starzl TE. The clinical trial of fk 506 as primary and rescue immunosuppression in adult cardiac transplantation. Transplant Proc. 1991;23:3054\u20133057.","journal-title":"Transplant Proc"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199801150-00021"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199808270-00016"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032953"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420902"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00237-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.02.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.07.022"},{"key":"e_1_3_3_13_2","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group: the international society for heart transplantation","volume":"9","author":"Billingham ME","year":"1990","unstructured":"Billingham ME, Cary NR, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group: the international society for heart transplantation. J Heart Transplant. 1990;9:587\u2013593.","journal-title":"J Heart Transplant"},{"key":"e_1_3_3_14_2","first-page":"754","article-title":"The international society for heart and lung transplantation grading system for heart transplant biopsy specimens: clarification and commentary","volume":"17","author":"Winters GL","year":"1998","unstructured":"Winters GL, Marboe CC, Billingham ME. The international society for heart and lung transplantation grading system for heart transplant biopsy specimens: clarification and commentary. J Heart Lung Transplant. 1998;17:754\u2013760.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80432-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00189-X"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00357-6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.035"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01314.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022171"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01290.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.08.014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02856.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00748.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.081"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.07.065"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.085"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.jpc60002"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.13.1561"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.13.1547"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000210538.93861.ae"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.110.958520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:26:44Z","timestamp":1715563604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.110.958520"}},"subtitle":["The Tacrolimus in Combination, Tacrolimus Alone Compared (TICTAC) Trial"],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.110.958520"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.110.958520","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"2010-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}