{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:15:40Z","timestamp":1773155740689,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>During heart failure (HF), cardiac metabolic substrate preference changes from fatty acid (FA) toward glucose oxidation. This change may cause progression toward heart failure. We hypothesize that a diet rich in FAs may prevent this process, and that dietary \u03c93-FAs have an added antiarrhythmic effect based on action potential (AP) shortening in animals with HF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Rabbits were fed a diet containing 1.25% (w\/w) high oleic sunflower oil (HF-\u03c99, N=11), 1.25% fish oil (HF-\u03c93, N=11), or no supplement (HF-control, N=8). Subsequently, HF was induced by volume and pressure overload. After 4 months, HF-parameters were assessed, electrocardiograms were recorded, and blood and ventricular tissue were collected. Myocytes were isolated for patch clamp or intracellular Ca\n              <jats:sup>2+<\/jats:sup>\n              - recordings to study electrophysiologic remodeling and arrhythmogenesis. Both the HF-\u03c99 and the HF-\u03c93 groups had larger myocardial FA oxidation capacity than HF control. The HF-\u03c93 group had significantly lower mean (\u00b1 SEM) relative heart and lung weight (3.3\u00b10.13 and 3.2\u00b10.12 g kg\n              <jats:sup>\u22121<\/jats:sup>\n              , respectively) than HF control (4.8\u00b10.30 and 4.5\u00b10.23), and shorter QTc intervals (167\u00b12.6 versus 182\u00b16.4). The HF-\u03c99 also displayed a significantly reduced relative heart weight (3.6\u00b10.26), but had similar QTc (179\u00b14.3) compared with HF control. AP duration in the HF-\u03c93 group was \u224820% shorter due to increased I\n              <jats:sub>to1<\/jats:sub>\n              and I\n              <jats:sub>K1<\/jats:sub>\n              and triggered activity, and Ca\n              <jats:sup>2+<\/jats:sup>\n              -aftertransients were less than in the HF-\u03c99 group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Dietary unsaturated FAs started prior to induction of HF prevent hypertrophy and HF. In addition, fish oil FAs prevent HF-induced electrophysiologic remodeling and arrhythmias.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.111.963116","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T04:56:24Z","timestamp":1333428984000},"page":"376-384","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload"],"prefix":"10.1161","volume":"5","author":[{"given":"Hester M.","family":"Den Ruijter","sequence":"first","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie O.","family":"Verkerk","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees A.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander M.","family":"Houten","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charly N.W.","family":"Belterman","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonius","family":"Baartscheer","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg A.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"van Bilsen","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baukje","family":"de Roos","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[{"name":"From the Experimental Cardiology Group of the Heart Center (H.M.D.R., C.A.S., C.N.W.B., A.B., R.C.) and the Department of Anatomy, Embryology and Physiology (A.O.V.), Laboratory Genetic Metabolic Diseases (S.M.H.), Academic Medical Center; Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam (I.A.B.); Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (M.V.B.); and the Rowett..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.014"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01967-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.018"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.022"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.733329"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90828-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16105-9"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.10.4427"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61239-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00854-4"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00460-7"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.026"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r19"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.07.006"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2974fje"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00044-5"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.565804"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4318"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.06.014"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp169"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.014"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.038"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn310"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn074"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1222"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02384.x"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.073"},{"key":"e_1_3_4_33_2","first-page":"145","article-title":"Etiology-dependency of ionic remodeling in cardiomyopathic rabbits","volume":"148","author":"Verkerk AO","year":"2009","unstructured":"Verkerk AO, Baartscheer A, de Groot JR, Wilders R, Coronel R. 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