{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:07:16Z","timestamp":1782515236636,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Small studies have reported women to have worse outcomes and more adverse events after implantation of mechanical circulatory support device compared with men. To further evaluate sex differences in outcome, we used the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              There were 401 women (pulsatile devices=78) and 1535 men (pulsatile devices=402) from 89 institutions who were prospectively enrolled into the INTERMACS database for primary implantation of a left ventricular assist device (LVAD) between June 23, 2006, and March 31, 2010. Extensive preimplantation and outcome data were collected on all patients. With a mean follow-up of 7 months, 67 females (17%) died and 250 males (16%) died. There was no statistically significant sex difference in mortality for either pulsatile-flow (\n              <jats:italic>P<\/jats:italic>\n              =0.82) or continuous-flow (\n              <jats:italic>P<\/jats:italic>\n              =0.95) devices in adjusted and unadjusted models. There were also no statistically significant sex differences with time to first infection, bleeding, or device malfunction. However, female sex was associated with an increased hazard of first neurological event (adjusted hazard ratio, 1.44; 95% CI, 1.05\u20131.96;\n              <jats:italic>P<\/jats:italic>\n              =0.020).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>There were no significant sex differences in mortality, time to first infection, bleeding, or device malfunction with either pulsatile- or continuous-flow LVADs. However, women had an increased risk of first neurological event. For urgent\/emergent mechanical support, the benefit of LVAD support likely outweighs the risk, but it remains less clear for women undergoing elective LVAD implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.111.963272","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T01:47:31Z","timestamp":1327024051000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":88,"title":["Should Women Receive Left Ventricular Assist Device Support?"],"prefix":"10.1161","volume":"5","author":[{"given":"Eileen M.","family":"Hsich","sequence":"first","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Naftel","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Myers","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiran Z.","family":"Gorodeski","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Grady","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene","family":"Schmuhl","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Ulisney","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Young","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Cleveland Clinic Foundation, Cleveland, OH (E.M.H., E.Z.G., D.S., J.B.Y.); Department of Surgery, University of Alabama at Birmingham, Birmingham, AL (D.C.N., S.L.M.); Department of Surgery, Northwestern University, Chicago, IL (K.L.G.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (K.L.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"S416","article-title":"Adverse event (AE) rates in patients receiving pulsatile VAD's: incidence and composition change dramatically 3 months after implant","volume":"28","author":"Kormos RL","year":"2009","unstructured":"Kormos RL, Teuteberg J, Kirklin JK, Naftel DC, Stevenson LW, Milano C, Miller M, Pagani FD, Rogers JG, Aaronson KD . Adverse event (AE) rates in patients receiving pulsatile VAD's: incidence and composition change dramatically 3 months after implant. J Heart Lung Transplant. 2009; 28: S416.","journal-title":"J Heart Lung Transplant."},{"key":"e_1_3_3_3_2","unstructured":"Summary of safety and effectiveness data. Premarket approval application number 060040. Thoratec heartmate II left ventricular assist system. April 2008. Available at http:\/\/www.Accessdata.Fda.Gov\/cdrh_docs\/pdf6\/p060040b.Pdf. 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