{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:39:19Z","timestamp":1791938359929,"version":"4.3.4"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>A change in allocation algorithm in July 2006 allowed broader regional sharing of donor hearts in the United States (US). We assessed if the allocation change has been associated with a decline in wait list mortality in the US.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We compared baseline characteristics and outcomes in patients \u226518 years old listed for a primary heart transplant in the US before (July 1, 2004\u2013July 11, 2006, Era1) and after (July 12, 2006\u2013June 30, 2009, Era 2) the change in allocation algorithm. Of 11 864 patients in the study, 4503 were listed during Era 1 and 7361 during Era 2. Patients listed during Era 2 were more likely to be listed status 1A, have an implantable cardioverter-defibrillator, and supported on a continuous flow assist device (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for distribution. Patients listed in Era 2 were at a 17% lower risk of dying on the wait list or becoming too sick to transplant (adjusted hazard ratio, 0.83, 95% CI 0.75, 0.93). Transplant recipients in Era 2 were more likely to be transplanted as status 1A (37% versus 48%, respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Post-transplant in-hospital mortality (6.3% versus 5.4%; adjusted odds ratio, 0.86 for Era 2, 95% CI 0.79, 1.06) and 1-year survival were similar.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The risk of death on the wait list or becoming too sick to transplant has decreased by 17% in the US since the allocation algorithm allowing broader regional sharing was implemented in 2006. The shift in hearts to sicker candidates has not resulted in higher in-hospital or first year post-transplant mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.111.964247","type":"journal-article","created":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T07:48:31Z","timestamp":1326527311000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Decline in Heart Transplant Wait List Mortality in the United States Following Broader Regional Sharing of Donor Hearts"],"prefix":"10.1161","volume":"5","author":[{"given":"Tajinder P.","family":"Singh","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Children's Hospital Boston, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Pediatrics, Harvard Medical School, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Cardiology, Cleveland Clinic, Cleveland, OH (D.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Almond","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Children's Hospital Boston, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Pediatrics, Harvard Medical School, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Cardiology, Cleveland Clinic, Cleveland, OH (D.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Children's Hospital Boston, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Pediatrics, Harvard Medical School, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Cardiology, Cleveland Clinic, Cleveland, OH (D.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionne A.","family":"Graham","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Children's Hospital Boston, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Pediatrics, Harvard Medical School, Boston, MA (T.P.S., C.S.A., D.A.G.); Department of Cardiology, Cleveland Clinic, Cleveland, OH (D.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00075-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.09.016"},{"key":"e_1_3_3_4_1","unstructured":"3. 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