{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:19:52Z","timestamp":1785449992449,"version":"3.56.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>There are limited data on the prognostic implications of brain natriuretic peptide (BNP) assessment in patients with mildly symptomatic heart failure (HF) who receive cardiac resynchronization therapy with a defibrillator (CRT-D).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The effect of elevated baseline and 1-year BNP levels (dichotomized at the upper tertile BNP of 120 pg\/mL) on the risk of HF or death was assessed among the cohort of 1197 patients with baseline BNP data enrolled in MADIT (Multicenter Automated Defibrillator Implantation Trial)-CRT. Elevated baseline BNP was associated with a significant 68% (\n              <jats:italic>P<\/jats:italic>\n              =0.007) and 58% (\n              <jats:italic>P<\/jats:italic>\n              =0.02) increase in the risk of HF or death among MADIT-CRT patients allocated to CRT-D and implantable cardioverter defibrillator-only therapy, respectively. At 1 year of follow-up, patients allocated to CRT-D displayed significantly greater reductions in BNP (26% reduction) levels compared with implantable cardioverter defibrillator-only patients (8% increase;\n              <jats:italic>P<\/jats:italic>\n              =0.005). Patients with CRT-D in whom 1-year BNP levels were reduced or remained low experienced a significantly lower risk of subsequent HF or death as compared with patients in whom 1-year BNP levels were high. Similarly, the echocardiographic response to CRT-D was highest among those who maintained low BNP levels or in whom BNP level at 1-year was reduced.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Our findings suggest that assessment of baseline and follow-up BNP provides important prognostic implications in patients with mildly symptomatic HF who receive CRT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00180271.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.112.000174","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T02:39:00Z","timestamp":1372214340000},"page":"998-1004","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Brain Natriuretic Peptide and Cardiac Resynchronization Therapy in Patients With Mildly Symptomatic Heart Failure"],"prefix":"10.1161","volume":"6","author":[{"given":"Andrew","family":"Brenyo","sequence":"first","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Barsheshet","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Rao","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Huang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jackson","family":"Hall","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick R.","family":"Peterson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J.","family":"Moss","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. Barsheshet, M.R., D.T.H., W.Z., S.M., A.J.M., I.G.), and the Department of Biostatistics (W.J.H., D.R.P.), University of Rochester Medical Center, Rochester, NY; and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (S.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A. Brenyo, A. 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