{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:07:12Z","timestamp":1791446832705,"version":"4.3.3"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Postoperative outcomes of patients with advanced heart failure undergoing ventricular assist device implantation are strongly influenced by their preoperative Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles. We sought to investigate whether a similar association exists in patients undergoing emergency heart transplantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              By means of the Spanish National Heart Transplant Registry database, we identified 704 adult patients treated with emergency heart transplantation in 15 Spanish centers between 2000 and 2009. Post-transplant outcomes were analyzed pertaining to patient preoperative INTERMACS profiles, which were retrospectively assigned by 2 blinded cardiologists. Before transplantation, INTERMACS profile 1 (critical cardiogenic shock) was present in 207 patients, INTERMACS profile 2 (progressive decline) in 291, INTERMACS profile 3 (inotropic dependence) in 176, and INTERMACS profile 4 (resting symptoms) was present in 30 patients. In-hospital postoperative mortality rates were, respectively, 43%, 26.8%, and 18% in patients with profiles 1, 2, and 3 to 4 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). INTERMACS 1 patients also presented the highest incidence of primary graft failure (1: 31.3%, 2: 22.3%, 3\u20134: 21.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.03) and postoperative need for dialysis (1: 33.2%, 2: 18.9%, 3\u20134: 21.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Adjusted odds-ratios for in-hospital postoperative mortality were 4.38 (95% confidence interval, 2.51\u20137.66) for profile 1 versus 3 to 4, 2.49 (95% confidence interval, 1.56\u20133.97) for profile 1 versus 2, and 1.76 (95% confidence interval, 1.02\u20133.03) for profile 2 versus 3 to 4. Long-term survival after hospital discharge was not influenced by preoperative INTERMACS profiles.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Preoperative INTERMACS profiles determine outcomes after emergency heart transplantation. Results call for a change in policies related to the management of heart transplant candidates presenting with INTERMACS profiles 1 and 2.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.112.000237","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T03:39:36Z","timestamp":1368589176000},"page":"763-772","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Preoperative INTERMACS Profiles Determine Postoperative Outcomes in Critically Ill Patients Undergoing Emergency Heart Transplantation"],"prefix":"10.1161","volume":"6","author":[{"given":"Eduardo","family":"Barge-Caballero","sequence":"first","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Segovia-Cubero","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Almenar-Bonet","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gonzalez-Vilchez","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Villa-Arranz","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Delgado-Jimenez","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Lage-Galle","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Perez-Villa","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Lambert-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Manito-Lorite","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Arizon-Del Prado","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicens","family":"Brossa-Loidi","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Pascual-Figal","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis De la","family":"Fuente-Galan","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Sanz-Julve","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mu\u00f1iz-Garcia","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Crespo-Leiro","sequence":"additional","affiliation":[{"name":"From the Heart Transplant Unit, Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain (E.B.-C., M.C.-L); Heart Transplant Unit, Hospital Puerta de Hierro, Madrid, Spain (J.S.-C.); Heart Transplant Unit, Hospital Universitario Politecnico La Fe, Valencia, Spain (L.A.-B.); Heart Transplant Unit, Hospital Marques de Valdecilla, Santander, Spain (F.G.-V.); Heart Transplant Unit, Hospital Gregorio Mara\u00f1on, Madrid, Spain (A.V.-A.); Heart Transplant Unit, Hospital Doce de Octubre, Madrid, Spain (J.D.-J.); Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.858076"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2012.07.012"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.028"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2581"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.02.015"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.04.033"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.10.016"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-1452"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2010.08.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2226"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2010.10.013"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.721"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e6f1eb"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.034"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.12.001"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.01.014"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.070"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c392"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs256"},{"key":"e_1_3_4_23_2","first-page":"33","article-title":"Registry of Circulatory and Respiratory Support: 1st report (2007\u20132010) of the Working Group on Mechanical Circulatory Assistance of the Spanish Society for Thoracic-Cardiovascular Surgery.","volume":"18","author":"Perez de la Sota E","year":"2011","unstructured":"Perez de la Sota E. Registry of Circulatory and Respiratory Support: 1st report (2007\u20132010) of the Working Group on Mechanical Circulatory Assistance of the Spanish Society for Thoracic-Cardiovascular Surgery. Cir Cardiov. 2011;18:33\u201340.","journal-title":"Cir Cardiov"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.112.000237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:23:27Z","timestamp":1715563407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.112.000237"}},"subtitle":["Analysis of the Spanish National Heart Transplant Registry"],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.112.000237"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.112.000237","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"2012-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}