{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:47:00Z","timestamp":1792666020235,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Acute cardiogenic shock after myocardial infarction is associated with high in-hospital mortality attributable to persisting low-cardiac output. The Impella\u2013EUROSHOCK-registry evaluates the safety and efficacy of the Impella-2.5\u2013percutaneous left-ventricular assist device in patients with cardiogenic shock after acute myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This multicenter registry retrospectively included 120 patients (63.6\u00b112.2 years; 81.7% male) with cardiogenic shock from acute myocardial infarction receiving temporary circulatory support with the Impella-2.5\u2013percutaneous left-ventricular assist device. The primary end point evaluated mortality at 30 days. The secondary end point analyzed the change of plasma lactate after the institution of hemodynamic support, and the rate of early major adverse cardiac and cerebrovascular events as well as long-term survival. Thirty-day mortality was 64.2% in the study population. After Impella-2.5\u2013percutaneous left-ventricular assist device implantation, lactate levels decreased from 5.8\u00b15.0 mmol\/L to 4.7\u00b15.4 mmol\/L (\n              <jats:italic>P<\/jats:italic>\n              =0.28) and 2.5\u00b12.6 mmol\/L (\n              <jats:italic>P<\/jats:italic>\n              =0.023) at 24 and 48 hours, respectively. Early major adverse cardiac and cerebrovascular events were reported in 18 (15%) patients. Major bleeding at the vascular access site, hemolysis, and pericardial tamponade occurred in 34 (28.6%), 9 (7.5%), and 2 (1.7%) patients, respectively. The parameters of age &gt;65 and lactate level &gt;3.8 mmol\/L at admission were identified as predictors of 30-day mortality. After 317\u00b1526 days of follow-up, survival was 28.3%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In patients with acute cardiogenic shock from acute myocardial infarction, Impella 2.5\u2013treatment is feasible and results in a reduction of lactate levels, suggesting improved organ perfusion. However, 30-day mortality remains high in these patients. This likely reflects the last-resort character of Impella-2.5\u2013application in selected patients with a poor hemodynamic profile and a greater imminent risk of death. Carefully conducted randomized controlled trials are necessary to evaluate the efficacy of Impella-2.5\u2013support in this high-risk patient group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.112.967224","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T16:00:29Z","timestamp":1354723229000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":297,"title":["Percutaneous Left-Ventricular Support With the Impella-2.5\u2013Assist Device in Acute Cardiogenic Shock"],"prefix":"10.1161","volume":"6","author":[{"given":"Alexander","family":"Lauten","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie E.","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jung","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Empen","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Erne","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); Department of Cardiology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands (A.E.E., J.P.S.H.); Department of Cardiology, Ernst-Moritz-Arndt University, Greifswald, Germany (K.E.); Division of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland (P.E.); Swiss Cardiovascular Center, Bern, Switzerland (S.C...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Klingenberg","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (Cardiology, Angiology, Pneumology), Friedrich-Schiller University, Erlanger Allee, Jena, Germany (A.L., C.J., H.R.F., M.F.); 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